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Iranian Journal of Basic Medical Sciences، جلد ۲۶، شماره ۱۱، صفحات ۱۳۳۴-۱۳۴۱
عنوان فارسی
چکیده فارسی مقاله
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عنوان انگلیسی Preparation and characterization of Tamoxifen loaded silica and NH2 functionalized mesoporous silica nanoparticles as delivery systems against MCF-7 breast cancer cells
چکیده انگلیسی مقاله Objective(s): Controlled drug delivery using nanotechnology enhances drug targeting at the site of interest and prevents drug dispersal throughout the body. This study focused on loading a poorly water-soluble drug Tamoxifen (TMX) into silica nanoparticles (SNPs) and amine-functionalized mesoporous silica nanoparticles (NH2-SBA-15). Materials and Methods: SNPs were prepared according to the Stöber method and functionalized with an amine group using 3-aminopropyl triethoxysilane (APTES) through a one-pot synthesis method to produce amine-functionalized mesoporous silica nanoparticles (NH2-SBA-15). Characterization of both nanoparticles was performed using FT-IR, FE-SEM, CHN analysis, porosity tests (BET), and dynamic light scattering (DLS). Results: The results showed an average particle size of 103.7 nm for SNPs and 225.9 nm for NH2-SBA-15. Based on the BET results, the pore size of NH2-SBA-15 was about 5.4 nm. In both silica nanoparticles, drug release at pH=5.7 was greater than that of pH=7.4. However, Tamoxifen-loaded NH2-SBA-15 (TMX@NH2-SBA-15) indicated the highest drug release in the acidic medium among TMX-loaded SNPs (TMX@SNPs), perhaps due to the high columbic repulsion in the functionalized NH2-SBA-15 nanoparticles. Regarding cytotoxicity results against MCF-7 breast cancer cell lines, both TMX@SNPs and TMX@NH2-SBA-15 nanoparticles exhibited greater cytotoxicity compared to the free TMX as a positive control. Although TMX@SNPs had a small size and high loading capacity, the cytotoxic effects were higher than those of TMX@NH2-SBA-15.Conclusion: Amine functionalization of SNPs can improve the potential activity of these nanoparticles for target therapy.
کلیدواژه‌های انگلیسی مقاله Amine-functionalized mesoporous silica nanoparticles (NH2-SBA-15), Breast Cancer, Drug Delivery, MCF-7 cells, Silica Nanoparticles, Tamoxifen
نویسندگان مقاله | Sepideh Taghavi
Department of Pharmaceutical Engineering, Medicinal Plants and Drugs Research Institute, Shahid Beheshti University, Tehran, Iran


| Mostafa Shahnani
Department of Pharmaceutical Engineering, Medicinal Plants and Drugs Research Institute, Shahid Beheshti University, Tehran, Iran


| Hasan Rafati
Department of Phytochemistry, Medicinal Plants and Drugs Research Institute, Shahid Beheshti University, Tehran, Iran
نشانی اینترنتی https://ijbms.mums.ac.ir/article_22766.html
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