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Iranian Journal of Otorhinolaryngology، جلد ۳۵، شماره ۵، صفحات ۲۷۳-۲۷۹
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عنوان انگلیسی Serum Level of Vitamin D in Patients with Salivary Gland Tumors
چکیده انگلیسی مقاله Introduction: The active vitamin D metabolites have anticancer effects on many human neoplasms. The vitamin D receptors have been detected in salivary glands tissue. This study aimed to evaluate the serum level of vitamin D in patients with malignant and benign salivary gland tumors. Materials and Methods: In this retrospective and cross-sectional study, 151 participants, including 42 patients with benign, 42 malignant salivary gland tumors, and 67 healthy subjects, participated. The serum level of vitamin D was measured using an enzyme-linked immunosorbent assay (ELISA). Results: The mean serum level of vitamin D was 42.7 ng/mL in patients with benign tumors, 40 ng/mL in malignant tumors, and 36.7 ng/mL in the control group. There was no significant difference between the mean vitamin D level and vitamin D status in patients with salivary gland tumors and normal controls (P=0.2). There was a significant positive correlation between vitamin D level and age in the control group (P=0.04). Conclusions: The results showed a high prevalence rate of vitamin D deficiency/insufficiency in salivary gland tumors and normal subjects, with no significant difference. Therefore, the serum level of vitamin D might not play a significant role in the pathogenesis of these tumors, similar to many human cancers. However, further prospective studies are recommended focusing on specific tumors and considering other interventional factors.
کلیدواژه‌های انگلیسی مقاله Cancer, Mucoepidermoid carcinoma, Pleomorphic adenoma, salivary gland, Vitamin D
نویسندگان مقاله | Sedigheh Moayedi
School of Dentistry, Mashhad University of Medical Sciences, Mashhad, Iran.


| Bijan Khademi
Otolaryngology Research Center, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran.


| Mahyar Malekzadeh
Institute of Cancer Research, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran.


| Golnoush Farzinnia
Oral and Dental Disease Research Center, School of Dentistry, Shiraz University of Medical Sciences, Shiraz, Iran.


| Zohreh Jaafari-Ashkavandi
Department of Oral and Maxillofacial Pathology, School of Dentistry, Shiraz University of Medical Sciences, Shiraz, Iran.
نشانی اینترنتی https://ijorl.mums.ac.ir/article_22942.html
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