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Basic and Clinical Neuroscience، جلد ۱۴، شماره ۵، صفحات ۰-۰
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چکیده فارسی مقاله
کلیدواژه‌های فارسی مقاله
عنوان انگلیسی The Association between Muscular Ultrasonographic Alterations and Clinical Symptoms in Patients with Inflammatory Myopathy
چکیده انگلیسی مقاله Purpose: Muscle biopsy is commonly used to diagnose inflammatory myopathies.  We evaluated the ability of muscle ultrasound (MUS), a non-invasive and simple tool, to distinguish between healthy subjects and individuals with inflammatory myopathy. Methods: This study was conducted on 17 patients with recently diagnosed biopsy-proven inflammatory myopathies (12 dermatomyositis, five polymyositis) compared with 17 age- and gender-matched healthy control adults. All patients underwent clinical assessments, including manual muscle testing (MMT) and hand-held dynamometry, as well as MUS evaluations, including thickness and echointensity (EI) in predefined muscle groups. Results: The disease duration was 7 (interquartile range: 3-11) months. Except for biceps and gastrocnemius, the patients' muscles had significantly higher EI and lower thickness in comparison with the controls, The EI sum-score manifested the highest area under curve (AUC) in comparison with the sum-scores of other variables (EI vs. MMT: AUCs-difference = 0.18, p < 0.01; EI vs. dynamometry: AUCs-difference = 0.14, p = 0.02; EI vs. thickness: AUCs-difference = 0.25, p < 0.01). Conclusion: Echointensity of muscles differed significantly between healthy individuals and those with inflammatory myopathies and may potentially serve as a useful diagnostic biomarker.
کلیدواژه‌های انگلیسی مقاله Case-control study, Inflammatory myopathy, Imaging, Muscle ultrasound
نویسندگان مقاله | Farzad Fatehi
Tehran University of Medical Sciences, Tehran, Iran.


| Parisa Khaghani
Tehran University of Medical Sciences, Tehran, Iran.


| Ali Asghar Okhovat
Tehran University of Medical Sciences, Tehran, Iran.


| Kamyar Moradi
Tehran University of Medical Sciences, Tehran, Iran.


| Farzad Teimouri
Tehran University of Medical Sciences, Tehran, Iran.


| Mahsa Mortaja
Tehran University of Medical Sciences, Tehran, Iran.


| Mahsa Layegh
Tehran University of Medical Sciences, Tehran, Iran.


| Akram Panahi
Tehran University of Medical Sciences, Tehran, Iran.


| Shahriar Nafissi
Tehran University of Medical Sciences, Tehran, Iran.
نشانی اینترنتی http://bcn.iums.ac.ir/browse.php?a_code=A-10-3567-1&slc_lang=en&sid=1
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کد مقاله (doi)
زبان مقاله منتشر شده en
موضوعات مقاله منتشر شده Clinical Neuroscience
نوع مقاله منتشر شده Original
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