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Iranian Journal of Public Health، جلد ۵۲، شماره ۱۰، صفحات ۲۰۹۹-۲۱۰۸
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عنوان انگلیسی Physical Activity, Sedentary Behavior, and Osteoarthritis: A Two-Sample Mendelian Randomization Analysis
چکیده انگلیسی مقاله Background: Sedentary behavior and physical activity are still ambiguous in their effects on osteoarthritis. We aimed to evaluate the effects of physical activity and sedentary behavior on osteoarthritis to provide a reference for the prevention of osteoarthritis. Methods: This study was conducted in Changchun, China in 2022. We used two-sample Mendelian randomization with the SNP as an instrumental variable to investigate the effect of physical activity and sedentary behavior on osteoarthritis. In addition, a two-step Mendelian randomization method was used to test whether mediating factors (BMI, smoking, Apolipoprotein B) were involved in mediating the effects of exposure factors on osteoarthritis. Results: TV watching was causally related to knee osteoarthritis and spine osteoarthritis, and they were positively correlated (knee osteoarthritis: OR=1.162,95 %CI: 1.027-1.315, P=0.017; spine osteoarthritis: OR=1.208,95 %CI: 1.033-1.413, P=0.018). BMI played a mediating role in the process of TV watching with knee osteoarthritis and spine osteoarthritis. ((The proportion of BMI mediating effect: knee osteoarthritis: 47.1% (95% CI: 36.7%~63.2%); spine osteoarthritis: 29.5% (95% CI: 19.3%~40.8%)). The proportion of Smoking mediating effect in the process of TV watching with spine osteoarthritis was 16.1% (95% CI: 3.7% ~ 31.6%). Conclusion: TV watching is a potential risk factor for osteoarthritis and plays a role through modifiable factors such as BMI and smoking, therefore, interventions on these factors have the potential to reduce the burden of osteoarthritis caused by longer TV watching times.
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نویسندگان مقاله | Yanpeng Wang
Department of Traditional Chinese Medicine, Changchun University of Chinese Medicine, Changchun 130117, China


| Yinzhen Zhang
Department of Traditional Chinese Medicine, Changchun University of Chinese Medicine, Changchun 130117, China


| Changwei Zhao
Department of Orthopedics, Affiliated Hospital of Changchun University of Chinese Medicine, Changchun 130021, China


| Wenjun Cai
Department of Orthopedics, The Third Affiliated Hospital of Changchun University of Chinese Medicine, Changchun 130399, China


| ZhengYan Wang
Department of Traditional Chinese Medicine, Changchun University of Chinese Medicine, Changchun 130117, China


| Wenhai Zhao
Department of Orthopedics, Affiliated Hospital of Changchun University of Chinese Medicine, Changchun 130021, China
نشانی اینترنتی https://ijph.tums.ac.ir/index.php/ijph/article/view/31595
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