| چکیده انگلیسی مقاله |
Objectives: In order to treat a rat model of rotator cuff rupture, this work concentrated on the expression of TNMD and RUNX2, followed by rotator cuff repair and secretome-hMSCs.Methods: A total of thirty 10-weeks-old male Sprague–Dawley rats were separated into five groups randomly, RC on week 0, lesion treated with a rotator cuff repair and saline (RC + NaCl group, n = 6) for 2 and 8 weeks, and lesion treated with a rotator cuff repair and secretome-hMSCs (RC + secretome-hMSC group, n = 6) for 2 and 8 weeks. The supraspinatus and infraspinatus muscle–tendon units were obtained for histological and biomechanical investigation at 0, 2 and 8 weeks following injury.Results: The findings showed that, in comparison with the RC + NaCl group, secretome-hMSCs significantly improved tendon repair by upregulating TNMD and RUNX2 expression and histology score.Conclusion: Combining Secretome-hypoxia MSCs with RC healing may help rats with rotator cuff tears. Level of evidence: IV |
| نویسندگان مقاله |
| Meiky Fredianto
1Orthopaedic and Traumatology Division, Surgery
Department, Universitas Muhammadiyah Yogyakarta,
Indonesia
2 Doctoral Study Program, Faculty of Medicine, Universitas
Padjajaran, Bandung, West Java, Indonesia
| Ambrosius Purba
2 Doctoral Study Program, Faculty of Medicine, Universitas
Padjajaran, Bandung, West Java, Indonesia
5 Department of Physiology, Faculty of Medicine, Universitas
Padjadjaran, Bandung Indonesia
| Yoyos Dias Ismiarto
2 Doctoral Study Program, Faculty of Medicine, Universitas
Padjajaran, Bandung, West Java, Indonesia
4 Department of Orthopaedics and Traumatology, Faculty of
Medicine, Universitas Padjadjaran, Indonesia
| Herrry Herman
2 Doctoral Study Program, Faculty of Medicine, Universitas
Padjajaran, Bandung, West Java, Indonesia
3 Division of Oncology, Department of Orthopaedic Surgery,
Faculty of Medicine, Universitas Padjadjaran, Bandung,
Indonesia
| Agung Putra
6 Stem Cell and Cancer Research, Semarang, Indonesia
7 Department of Postgraduate Biomedical Science, Faculty of
Medicine, Universitas Islam Sultan Agung (UNISSULA),
Semarang, Indonesia
8 Department of Pathological Anatomy, Faculty of Medicine,
Universitas Islam Sultan Agung (UNISSULA), Semarang,
Indonesia
| Nurul Hidayah
6 Stem Cell and Cancer Research, Semarang, Indonesia
9 Graduate student in Biotechnology Department, Graduate
School, Universitas Gadjah Mada, Yogyakarta, Indonesia
|