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Journal of Food Quality and Hazards Control، جلد ۱۰، شماره ۳، صفحات ۱۵۳-۱۶۲
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عنوان انگلیسی Evaluation of Antimicrobial and Structural Properties of Thyme Essential Oil-Loaded Chitosan-Capric Acid and Chitosan-Stearic Acid Nanogels
چکیده انگلیسی مقاله Background: This study aimed to investigate the physicochemical properties, antimicrobial activity, and cytotoxicity of Thyme Essential Oil (TEO) encapsulated by chitosan nanogels. Methods: In this study, chitosan-stearic acid and chitosan-capric acid nanogels were developed in two ratios of chitosan to fatty acid (10: 1 and 10: 3). Results: The results of Fourier-Transform Infrared Spectroscopy analysis showed a successful binding of chitosan to capric and stearic acids. Scanning Electron Microscope images revealed that particle formation improved with increase of the ratio of fatty acid to chitosan. The antimicrobial capacity of both encapsulation systems on three species of microorganisms (Staphylococcus aureus, Escherichia coli, and Candida albicans) was studied. A sustained release of curcumin was observed in Simulated Intestine Fluid. The developed nanogels did not have any toxicity on different cell lines. The results also showed that the antimicrobial capacity of TEO encapsulated with chitosan nanogels was higher (p< 0.05) than the ionic method (use of sodium triphosphate incorporating chitosan). Conclusion: The results have shown that encapsulating TEO in chitosan nanogels is a suitable alternative for synthetic antibiotics in different products. DOI: 10.18502/jfqhc.10.3.13646
کلیدواژه‌های انگلیسی مقاله Thymus Plant, Chitosan, Nanogels, Oils, Volatile
نویسندگان مقاله | A. Rajaei
Department of Food Science and Technology, University of Shahrood, Shahrood, Iran


| D. Salarbashi
Department of Food Science, Nutrition and Clinical Biochemistry, School of Medicine, Gonabad University of Medical Sciences, Gonabad, Iran, Research Center for Food Hygiene and Safety, School of Public Health, Shahid Sadoughi University of Medical Sciences, Yazd, Iran


| ‪M. Tafaghodi
Nanotechnology Research Center, Pharmaceutical Technology Institute, Mashhad University of Medical Sciences, Mashhad, Iran, Pharmaceutics Department, School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, Iran


| Z. Sabeti
Department of Biopathology, Faculty of Veterinary Medicine, Ferdowsi University of Mashhad, Mashhad, Iran, Pharmaceutical Control Department, School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, Iran


| F. Sabbagh
Department of Chemical Engineering, Chungbuk National University, Cheongju, Chungbuk 28644, Republic of Korea


| S. Rakhshani
Department of Biopathology, Faculty of Veterinary Medicine, Ferdowsi University of Mashhad, Mashhad, Iran, Department of Pharmaceutics, School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, Iran


| H. Kamali
Department of Pharmaceutics, School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, Iran, Targeted Drug Delivery Research Center, Pharmaceutical Technology Institute, Mashhad University of Medical Sciences, Mashhad, Iran


| E. Fahmideh-Rad
Department of Applied Sciences, College of Applied Sciences and Pharmacy, University of Technology and Applied Sciences, Muscat, Oman
نشانی اینترنتی http://jfqhc.ssu.ac.ir/browse.php?a_code=A-10-1644-1&slc_lang=en&sid=1
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زبان مقاله منتشر شده en
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نوع مقاله منتشر شده Original article
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