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Avicenna Journal of Phytomedicine، جلد ۱۳، شماره ۶، صفحات ۶۱۵-۶۲۵
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عنوان انگلیسی Effect of nano-micelle curcumin on hepatic enzymes: A new treatment approach for non-alcoholic fatty liver disease (NAFLD)
چکیده انگلیسی مقاله Objective: Nonalcoholic fatty liver disease (NAFLD) is characterized by excessive lipid accumulation in hepatocytes with no consumption of alcohol. Recently, curcumin is a natural polyphenol found in turmeric has been examined for the treatment of NAFLD. This study aimed to assess the efficacy of 160 mg/day nano-micelle curcumin on the amelioration of NAFLD by measuring liver enzymes.Materials and Methods: Patients with NAFLD were randomly divided into curcumin (intervention group n=33) and placebo (n=33) groups and at the end of the study, the data of 56 participants who completed the 2-month intervention were analyzed. Laboratory tests and questionnaires were used to gather information. Both groups received recommendations for lifestyle modification, and were advised to other necessary advices. Patients in the curcumin group received 160 mg/day of nano-micelle curcumin in two divided doses for 60 days. The 2 groups were followed up for two months and clinical and laboratory indices were compared.Results: Our data showed a significant decrease in alanine aminotransferase (ALT) and aspartate aminotransferase (AST) in the curcumin group (p< 0.01) as well as a significant difference between the groups before and after the intervention in curcumin group (p< 0.05). Interestingly, a meaningful decrease in AST serum level was observed in the intervention group (p< 0.01). Conclusion: Our study demonstrated that short-term supplementation with nano-micelle curcumin results in the reduction of AST and ALT and is beneficial for the treatment of NAFLD.
کلیدواژه‌های انگلیسی مقاله Non-alcoholic fatty liver disease, Curcumin, Nano-micelle, Hepatic enzymes
نویسندگان مقاله | Ali Beheshti Namdar
Department of Internal Medicine, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran


| Mitra Ahadi
Department of Internal Medicine, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran


| Seyed Mousalreza Hoseini
Department of Internal Medicine, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran


| Hassan Vosoghinia
Department of Internal Medicine, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran


| Hosein Rajablou
Student Research Committee, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran


| Salman Farsi
Student Research Committee, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran


| Amirsadra Zangouei
Student Research Committee, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran


| Hamid Reza Rahimi
Department of Medical Genetics & Molecular Medicine, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran
نشانی اینترنتی https://ajp.mums.ac.ir/article_21919.html
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نوع مقاله منتشر شده Original Research Article
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