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Avicenna Journal of Phytomedicine، جلد ۱۳، شماره ۶، صفحات ۶۲۶-۶۴۰
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عنوان انگلیسی Identification of Lilium ledebourii antiproliferative compounds against skin, bone and oral cancer cells
چکیده انگلیسی مقاله Objective: This study aimed at the evaluation of anti antiproliferative activity of Lonicera nummularifolia, Lilium ledebourii, Campsis radicans and Parthenocissus quinquefolia extracts. Materials and Methods: The extract was taken from the fresh leaves and bulbs of the plants by maceration method in the dark. After separating the solvent, the remaining dry matter was added to the culture medium containing G292, A431 and KB cancer and HGF-1 normal cells. Cytotoxicity tests, as well as cell cycle and apoptosis tests were performed on cells treated with dry substances and untreated cells. Finally, the most effective extract was separated into fractions by preparative HPLC and the effective fraction w::as char::acterized by Triple-Quad LC/MS connected to the UHPLC system.Results: All extracts significantly enhanced cell death rate in the three cancer cell lines more than the HGF-1 line. The Methanolic extract of L. ledebourii bulbs exhibited considerable efficacy on apoptosis induction in the cancer cell lines. It seems that the mode of action for L. ledebourii methanolic extract is mediated through increased BID/MAPK14 expression and decreased MDM2/BCL2/MYC expression, which led to activation of the p53 protein-induced apoptosis. It was also determined that the effective fraction of L. ledebourii methanolic extract consists of substances such as caffeic acid, ferulic acid, coumarin acid, catechin and apigenin.Conclusion: Overall, the findings suggest that L. ledebourii is a promising source of bioactive compounds with anticancer properties.
کلیدواژه‌های انگلیسی مقاله Apoptosis, A431 cell line, KB cell line, G292 cell line, Phytochemicals
نویسندگان مقاله | Nastaran Partovi
Department of Plant Biotechnology, Faculty of Agriculture, University of Guilan, Rasht, Iran


| Hassan Hassani Kumleh
Department of Plant Biotechnology, Faculty of Agriculture, University of Guilan, Rasht, Iran


| Ebrahim Mirzajani
Department of Biochemistry, Faculty of Medicine, Guilan University of Medical Sciences, Rasht, Iran


| Mohsen Farhadpour
Phytochemistry Group, National Institute of Genetic Engineering and Biotechnology, Tehran, Iran
نشانی اینترنتی https://ajp.mums.ac.ir/article_22875.html
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زبان مقاله منتشر شده en
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نوع مقاله منتشر شده Original Research Article
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