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Avicenna Journal of Phytomedicine، جلد ۱۳، شماره ۶، صفحات ۶۵۱-۶۶۴
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عنوان انگلیسی Ellagic acid alleviates motor, cognitive and hippocampal electrical activity deficits in the male rats with 2-vessel occlusion cerebral ischemia/reperfusion
چکیده انگلیسی مقاله Objective: Cerebral ischemia/reperfusion (I/R) has been known as a major cause of inability and mortality worldwide. Ellagic acid (EA) has many pharmacological effects including antioxidant, antithrombotic and neurorestoration activities. The aim of this study was evaluation of the effects of EA on motor and cognitive behaviors, hippocampal local field potential (LFP), brain oxidative stress in male rats with cerebral 2-vessel occlusion ischemia/reperfusion (2VO I/R).Materials and Methods: Forty-eight male Wistar rats (250-300 g) were assigned into six groups. 1) The Sham: rats were treated with DMSO10%/normal saline as solvent of EA 3 times daily for 1 week; 2) I/R+Veh; I/R rats received vehicle; 3-5) EA-treated groups: I/R rats received 50, 75, or 100 mg/kg EA; and 6) Cont+EA100: intact rats received EA. The cerebral 2VO I/R was made by the bilateral common carotid arteries closing for 20 min followed by reperfusion. The behavioral tests and hippocampal LFP recording were performed after treatment with EA. The oxidative stress parameters were assayed by special ELISA kits.Results: Cerebral 2VO I/R significantly decreased motor coordination, memory and hippocampal LFP and significantly increased oxidative stress. Treatment with EA improved all I/R complications. Conclusion: The current findings showed that treatment of I/R rats with EA could reverse cognitive and motor functions, and improve the LFP and oxidative stress markers. So, effects of EA on cognitive and motor function may at least in part, be due to its antioxidative actions.
کلیدواژه‌های انگلیسی مقاله Cerebral ischemia/reperfusion, Ellagic acid, Motor coordination, Cognition, Hippocampal local EEG, Oxidative stress
نویسندگان مقاله | Khadijeh Hassonizadeh Falahieh
Department of Physiology, College of Sciences, Science and Research Branch, Islamic Azad University, Fars, Iran


| Alireza Sarkaki
Persian Gulf Physiology Research Center, Medical Basic Research Institute and Department of Physiology Faculty of Medicine, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran


| Mohammadamin Edalatmanesh
Department of Physiology, College of Sciences, Shiraz Branch, Islamic Azad University, Shiraz, Iran


| Mohammad Kazem Gharib Naseri
Persian Gulf Physiology Research Center, Medical Basic Sciences Research Institute, Ahvaz Jundishapur University of Medical Science, Ahvaz, Iran


| Yaghoob Farbood
Persian Gulf Physiology Research Center, Medical Basic Sciences Research Institute and Department of Physiology, Ahvaz Jundishapur University of Medical Science, Ahvaz, Iran
نشانی اینترنتی https://ajp.mums.ac.ir/article_22787.html
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زبان مقاله منتشر شده en
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نوع مقاله منتشر شده Original Research Article
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