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Physiology and Pharmacology، جلد ۲۷، شماره ۳، صفحات ۲۱۱-۲۳۳
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عنوان انگلیسی An overview of animal models induced by glucocorticoids
چکیده انگلیسی مقاله Glucocorticoids are widely employed for treating various disorders, but their administration is associated with multiple adverse effects. To study and understand these side effects, preclinical animal models have been developed. Experimental models that replicate essential aspects of human diseases offer valuable tools for assessing potential therapeutic agents and elucidating molecular and cellular pathways in a controlled environment. In this review, we provide an overview of various animal models in which glucocorticoids have been utilized to induce humanlike disorders across different body systems. These disorders encompass hypertension, skin atrophy, hair loss, insulin resistance, dyslipidemia, gastric mucosal damage, growth retardation, muscle atrophy, osteoporosis, osteonecrosis, depression-like behavior, glaucoma, and cataracts.
کلیدواژه‌های انگلیسی مقاله Animal Experimentation, Glucocorticoid, Mice, Model, Rat
نویسندگان مقاله | Azadeh Mesripour
Department of Pharmacology and Toxicology, Isfahan Pharmaceutical Sciences Research Center, School of Pharmacy and Pharmaceutical Sciences, Isfahan University of Medical Sciences, Isfahan, Iran


| Mansooreh Asghari-Varzaneh
Department of Pharmacology and Toxicology, Isfahan Pharmaceutical Sciences Research Center, School of Pharmacy and Pharmaceutical Sciences, Isfahan University of Medical Sciences, Isfahan, Iran


| Leila Safaeian
Department of Pharmacology and Toxicology, Isfahan Pharmaceutical Sciences Research Center, School of Pharmacy and Pharmaceutical Sciences, Isfahan University of Medical Sciences, Isfahan, Iran
نشانی اینترنتی http://ppj.phypha.ir/browse.php?a_code=A-13-1764-1&slc_lang=en&sid=1
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کد مقاله (doi)
زبان مقاله منتشر شده en
موضوعات مقاله منتشر شده Endocrine Physiology/Pharmacology
نوع مقاله منتشر شده Review
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