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Physiology and Pharmacology، جلد ۲۷، شماره ۳، صفحات ۲۵۴-۲۶۰
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عنوان انگلیسی The effect of tempol, a potent synthetic antioxidant, on the limb teratogenicity in an experimental model of preeclampsia in rats
چکیده انگلیسی مقاله Introduction: Preeclampsia is the principal cause of maternal morbidity and is characterized by hypertension, proteinuria, and edema. It is believed that oxidative stress plays an essential role in the pathophysiology of preeclampsia. This study was conducted to determine the effect of tempol on fetal limb hemorrhage, malformations, and oxidative stress in an N-nitro-L-arginine methyl ester (L-NAME)-induced preeclamptic rat model. Methods: To induce preeclampsia, L-NAME (50 mg/kg/day, oral) was administered from day 11 of pregnancy to day 22. Four preeclamptic groups received L-NAME alone, L-NAME+tempol (20, 60, 180 mg/kg/day; L-NAME, L-T20, L-T60, L-T180 groups, respectively). The control group (normal pregnant) received only tap water, and the T60 group received tempol (60 mg/Kg) alone (without L-NAME). The concentration of 8-isoprostane in plasma and placenta, number and weight of the fetuses, and the limb defects were measured on the 22nd day of the pregnancy. Results: L-NAME administration caused placental oxidative stress, limb defects and hemorrhage, and low fetal weight. Administration of tempol at 20 and 60 mg/kg/day reduced limb defects (10.5 and 7.2 percent versus 24.7 percent) and limb hemorrhage (14.5 and 9.5 percent versus 23 percent) induced by L-NAME. After administration of tempol (20 and 60 mg/kg), fetal weight increased (5.14±0.08 and 5.44±0.15 versus 4.27± 0.11 g). Administration of tempol at the high dose (180 mg/kg/day) did not produce any significant effects on the measured parameters. Conclusion: Tempol with certain doses improves fetal outcomes in an experimental rat model of preeclampsia. These may be the results of its antioxidant action.
کلیدواژه‌های انگلیسی مقاله Limb malformation, L-NAME, Oxidative stress, Preeclampsia,Tempol
نویسندگان مقاله | Mohammadreza Namavar
1Clinical Neurology Research Center, Shiraz University of Medical Sciences, Shiraz, Iran; 2Histomorphometry and Stereology Research Center & Department of anatomical Sciences, Shiraz


| mohammad sharif talebianpoor
Herbal Medicine Research Center, School of Medicine, Yasouj University of Medical Sciences, Yasouj, Iran


| Somayeh Nazari
Medicinal & Natural Products Chemistry Research Center, Shiraz University of Medical Sciences, Shiraz, Iran


| Hossein Mirkhani
Department of Pharmacology, Shiraz University of Medical Sciences, Shiraz, Iran
نشانی اینترنتی http://ppj.phypha.ir/browse.php?a_code=A-10-1630-1&slc_lang=en&sid=1
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کد مقاله (doi)
زبان مقاله منتشر شده en
موضوعات مقاله منتشر شده Pharmacokinetics/Dynamics
نوع مقاله منتشر شده Experimental research article
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