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Physiology and Pharmacology، جلد ۲۷، شماره ۳، صفحات ۲۶۱-۲۷۰
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عنوان انگلیسی Toxicity assessment of a polyherbal drug on haematological parameters, brain and spleen histoarchitecture in exposed Wistar rats
چکیده انگلیسی مقاله Introduction: We investigated the subchronic toxicity concerns of a polyherbal formulation (PHF; Dr Iguedo Goko Cleanser®) on haematological indices, brain and spleen histomorphology in exposed Wistar rats of both sexes. Methods: Thirty Wistar rats randomly allotted to six groups (5/group) were experimentally exposed to PHF via the oral route for 60 days as follows: control groups (1 and 4; given 5ml/kg distilled water); groups 2, 5 (476.24mg/kg) and 3, 6 (158.75mg/kg) body weight PHF, respectively. On 62nd day, animals were euthanized using carbon dioxide and sacrificed; spleen and brain tissues were evis-cerated, weighed and fixed in 10% buffered-formalin for histopathological assessment. Results: Our results showed significant increase in platelet in all experimental rats relative to control. Low dosed (158.75mg/kg) male rats recorded a significant increase in WBC relative to control. Also increased were MCV and MCH in male rats. High dosed female rats had increased RBC and MCV. Neutrophils and lymphocyte differentials were respectively decreased and increased in experimental groups relative to control. Histopathology of the spleen and brain tissues revealed degrees of pathologies like abnormal cytostructure of lymphoid follicle, degenerated T-lymphocytes, numerous organic deposits, degenerating neural cells, proliferating astrocytes, widely scattered blood vessel amongst others. Conclusion: Our findings revealed exposure-associated toxic effects of the quasi-drug formulation on blood parameters and histostructure of the spleen and brain. Findings suggest utmost caution on long-term use of the polyherbal formulation and avoidance whenever possible.
کلیدواژه‌های انگلیسی مقاله Drug compounding, Herbal medicine, Toxicology, Gliosis, Haematology
نویسندگان مقاله | Godswill J. Udom
Department of Pharmacology and Toxicology, Faculty of Pharmacy, Federal University Oye-Ekiti


| Uduak P. Ise


| Ayodeji Aturamu


| Moses A. Omoirri


| Mba Ogbonnaya


| Israel K. Umana


| Jude E. Okokon


نشانی اینترنتی http://ppj.phypha.ir/browse.php?a_code=A-10-1700-1&slc_lang=en&sid=1
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کد مقاله (doi)
زبان مقاله منتشر شده en
موضوعات مقاله منتشر شده Toxicology
نوع مقاله منتشر شده Experimental research article
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