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Cell Journal، جلد ۲۵، شماره ۱۱، صفحات ۷۹۰-۸۰۰
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عنوان انگلیسی The Effect of Mesenchymal Stem Cells Derived-Conditioned Media in Combination with Oral Anti-Androgenic Drugs on Male Pattern Baldness: An Animal Study
چکیده انگلیسی مقاله Objective: Androgenetic alopecia (AGA) is a prevalent form of hair loss, mainly caused by follicular sensitivity to
androgens. Despite developing different anti-androgen treatment options, the success rate of these treatments has
been limited. Using animal models, this study evaluated the therapeutic effects of umbilical cord (UC) stem cell
conditioned media (CM) combined with oral anti-androgens for hair regeneration.
Materials and Methods: In this experimental study, Poloxamer 407 (P407) was used as a drug carrier for
subcutaneous testosterone injection. AGA models were treated with oral finasteride, oral flutamide, and CM
injections. Samples were thoroughly evaluated and compared using histological, stereological, and molecular
analyses.
Results: Injecting CM-loaded hydrogel alone or combined with oral intake of anti-androgens improved hair regeneration.
These treatments could promote hair growth by inducing hair follicles in the anagen stage and shortening the telogen
and catagen phases. Furthermore, the combination treatment led to an upregulation of hair induction gene expression
with a downregulation of inflammation genes.
Conclusion: Through a reduction in inflammation, injection of CM-loaded hydrogel alone or combined with oral intake
of anti-androgens induces the hair cell cycle with regeneration in damaged follicles. Hence, this could be a promising
therapeutic method for AGA patients.
کلیدواژه‌های انگلیسی مقاله Androgenetic Alopecia, Conditioned Media, Finasteride, Flutamide, Mesenchymal stem cells
نویسندگان مقاله Majid Kamali-Dolat Abadi |
Department of Tissue Engineering and Applied Cell Sciences, School of Advance Medical Science and Technology, Shiraz University of Medical Sciences, Shiraz, Iran

Gholamhossein Yousefi |
Department of Pharmaceutics, School of Pharmacy, Shiraz University of Medical Sciences, Shiraz, Iran

Farzaneh Dehghani |
Histomorphometry and Stereology Research Center, Shiraz University of Medical Sciences, Shiraz, Iran

Ali Akbar Alizadeh |
Department of Tissue Engineering and applied cell science, School of Advanced Medical Sciences & Technologies, Shiraz University of Medical Sciences, Shiraz, Iran

Abolfazl Jangholi |
Department of Biology, Faculty of Science, Razi University, Kermanshah, Iran

Mohammad Amin Moadab |
Department of Biology, Zand Institute of Higher Education, Shiraz, Iran

Maryam Naseh |
Histomorphometry and Stereology Research Center, Shiraz University of Medical Sciences, Shiraz, Iran

Shima Parsa |
Transplant Research Center, Shiraz University of Medical Sciences, Shiraz, Iran

Golara Nasiri |
Department of Tissue Engineering and Cell Therapy, School of Advanced Technologies in Medicine, Shiraz University of Medical Sciences, Shiraz, Iran

Negar Azarpira |
Transplant Research Center, Shiraz University of Medical Sciences, Shiraz, Iran

Mehdi Dianatpour |
Stem Cell Technology Research Center, Shiraz University of Medical Sciences, Shiraz, Iran

نشانی اینترنتی https://www.celljournal.org/article_708272_d1ad4f96aa75fd74e3d5dda86791f3a2.pdf
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