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Cell Journal، جلد ۲۵، شماره ۸، صفحات ۵۶۴-۵۶۹
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عنوان انگلیسی Increased Apoptosis in Subcortical Regions of The Visual Pathway in Offspring Born to Diabetic Rats
چکیده انگلیسی مقاله Objective: Diabetes in pregnancy is a prevalent disease that can affect the central nervous system of the fetus by
hyperglycemia. This study aimed to investigate the impact of maternal diabetes on neuronal apoptosis in the superior
colliculus (SC) and the lateral geniculate nucleus (LGN) in male neonates born to diabetic mothers.
Materials and Methods: In this experimental study, female adult rats were separated into three groups: control,
diabetic (induced using an intraperitoneal injection of streptozotocin), and insulin-treated diabetic [diabetes controlled
by subcutaneous neutral protamine hagedorn (NPH)-insulin injection]. Male neonates from each group were euthanized
on 0, 7, and 14 postnatal days (P0, P7, and P14, respectively), and apoptotic cells were identified using TUNEL staining.
Results: The numerical density per unit area (NA) of apoptotic cells was significantly higher in SC and the dorsal
LGN (dLGN) in neonates born to the diabetic rats compared to the control group at P0, P7, and P14. However, insulin
treatment normalized the number of apoptotic cells.
Conclusion: This study demonstrated that maternal diabetes increased apoptosis in dLGN and SC of male neonates
at P0, P7, and P14.
کلیدواژه‌های انگلیسی مقاله Apoptosis, Lateral geniculate nucleus, Maternal diabetes, Rat brain, Superior colliculus
نویسندگان مقاله Nasim Alipour |
Department of Anatomy and Cell Biology, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran

Somaye Fallahnezhad |
Nervous System Stem Cell Research Center, Semnan University of Medical Sciences, Semnan, Iran

Javad Bagheri |
Department of Anatomy and Cell Biology, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran

Hamideh Babaloo |
Department of Advanced Medical Sciences and Technologies, School of Paramedicine, Shahid Sadoughi University of Medical Sciences, Yazd, Iran

Fatemeh Tahmasebi |
Department of Anatomy and Cell Biology, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran

Ghasem Sazegar |
Department of Anatomy and Cell Biology, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran

Hossein Haghir |
Department of Anatomy and Cell Biology, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran

نشانی اینترنتی https://www.celljournal.org/article_705397_816b6c42b833c219246aeb1ea8563e92.pdf
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