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Cell Journal، جلد ۲۵، شماره ۴، صفحات ۲۱۷-۲۲۱
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عنوان انگلیسی The Effect of Amniotic Membrane Extracted Eye Drop on Repairing The Corneal Epithelial in Patients after Trans-Epithelial Photorefractive Keratectomy: An Interventional and Historical Study
چکیده انگلیسی مقاله Objective: Recent studies imply extensive applications for the human amniotic membrane (hAM) and its extract in
medicine and ophthalmology. The content of hAM meets many requirements in eye surgeries, such as refractive
surgery as the most important and commonly used method for treating the dramatically increasing refractive errors.
However, they are associated with complications such as corneal haziness and corneal ulcer. This study was designed
to evaluate the impact of amniotic membrane extracted eye drop (AMEED) on Trans-PRK surgery complications.
Materials and Methods: This interventional and historical study was performed during two years (July 1, 2019-September
1, 2020). Thirty-two patients (64 eyes), including 17 females and 15 males, aged 20 to 50 years (mean age of 29.59 ±
6.51) with spherical equivalent between -5 to -1.5 underwent Trans Epithelial Photorefractive Keratectomy (Trans-PRK)
surgery. One eye was selected per case (case group) and the other eye was considered as control. Randomization
was done using the random allocation rule. The case group was treated with AMEED, and the artificial tear drop every
4 hours. The control eyes received artificial tear drops instilled every 4 hours. The evaluation continued for three days
after the Trans-PRK surgery.
Results: A significant decrease in CED size was found in the AMEED group on the second day after surgery (P=0.046).
Also, this group had a substantial reduction in pain, hyperemia, and haziness.
Conclusion: This study showed that AMEED drop can increase the healing rate of corneal epithelial lesions after Trans-
PRK surgery and reduce the early and late complications of Trans-PRK surgery. Researchers and Ophthalmologists
should consider AMEED as a selection in patients with persistent corneal epithelial defects and patients who have
difficulty in corneal epithelial healing. We understood AMEED has a different effect on the cornea after surgery;
therefore, the researcher must know AMEED’s exact ingredients and help expand AMEED uses.
کلیدواژه‌های انگلیسی مقاله Amnion, Photorefractive Keratectomy, Refractive Surgical Procedures, Wound healing
نویسندگان مقاله Alireza Ranaei |
Student Research Committee, Baqiyatallah University of Medical Sciences, Tehran, Iran

Ahmad Chavoshi |
Student Research Committee, Baqiyatallah University of Medical Sciences, Tehran, Iran

Hossein Aghamollaei |
Chemical Injures Research Center, Systems Biology and Poisonings Institute, Baqiyatallah University of Medical Sciences, Tehran, Iran

Mostafa Naderi |
Chemical Injures Research Center, Systems Biology and Poisonings Institute, Baqiyatallah University of Medical Sciences, Tehran, Iran

Ali Agha Alishiri |
Chemical Injures Research Center, Systems Biology and Poisonings Institute, Baqiyatallah University of Medical Sciences, Tehran, Iran

Khosrow Jadidi |
Chemical Injures Research Center, Systems Biology and Poisonings Institute, Baqiyatallah University of Medical Sciences, Tehran, Iran

نشانی اینترنتی https://www.celljournal.org/article_703269_5ed54d0474243192588c3712bec10844.pdf
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