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Cell Journal، جلد ۲۵، شماره ۱، صفحات ۷۳-۷۵
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چکیده فارسی مقاله
کلیدواژه‌های فارسی مقاله
عنوان انگلیسی Healthy Male Individuals Possess Higher Plasma HER-2 Level than Females
چکیده انگلیسی مقاله Considering HER2 as one of the well-known biomarkers in the cancer field, and published articles regarding serum
levels of HER2, in this paper we tried to highlight the issue that most studies don’t stratify the HER-2 concentration
of individuals in terms of gender. In this brief survey, healthy individuals with no prior non-communicable diseases
were categorized as males (n=34) and females (n=43), and all samples were evaluated for plasma HER-2 levels
at once. Surprisingly, the plasma level of HER-2 of healthy male individuals (mean= 2.28 ± 0.21 ng/mL) was
significantly (P<0.0001) higher than the plasma level of HER-2 of healthy females (mean: 0.06 ± 0.09 ng/mL),
with no overlap. Therefore, we suggest that more studies are required to re-check the cutoff values for HER-2
plasma levels based on gender since the clinical implications of a unique HER-2 cutoff for both genders may be
seriously concerning.
کلیدواژه‌های انگلیسی مقاله Biomarkers, neoplasm invasiveness/diagnosis, liquid biopsy
نویسندگان مقاله Sepand Tehrani Fateh |
School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran

Abbas Behgozin |
R&D Division, Tashkhis Fan Firoozeh (Firoozeh DiaTech), Tehran, Iran

Farshid Yekani |
R&D Division, Tashkhis Fan Firoozeh (Firoozeh DiaTech), Tehran, Iran

Lobat Geranpayeh |
Department of Surgery, Sina Hospital, Tehran University of Medical Sciences, Tehran, Iran

Asieh Olfatbakhsh |
Breast Diseases Department, Breast Cancer Research Center, Motamed Cancer Institute, ACECR, Tehran, Iran

Shiva Moghaddam |
Breast Diseases Department, Breast Cancer Research Center, Motamed Cancer Institute, ACECR, Tehran, Iran

Ramin Sarami Forroshani |
ATMP Department, Breast Cancer Research Center, Motamed Cancer Institute, ACECR, Tehran, Iran

Amir Salehi-Najafabadi |
R&D Division, Tashkhis Fan Firoozeh (Firoozeh DiaTech), Tehran, Iran

Faezeh Shekari |
R&D Division, Tashkhis Fan Firoozeh (Firoozeh DiaTech), Tehran, Iran

نشانی اینترنتی https://www.celljournal.org/article_699767_16206cbf7c038941c45d5e403535475e.pdf
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