این سایت در حال حاضر پشتیبانی نمی شود و امکان دارد داده های نشریات بروز نباشند
Cell Journal، جلد ۲۳، شماره ۳، صفحات ۳۱۳-۳۱۸
عنوان فارسی
چکیده فارسی مقاله
کلیدواژه‌های فارسی مقاله
عنوان انگلیسی Association between rs11614913 Polymorphism of The MiR-196-a2 Gene and Colorectal Cancer in The Presence of Departure from Hardy-Weinberg Equilibrium
چکیده انگلیسی مقاله Objective
Colorectal cancer (CRC) is the fourth most common and the second most lethal cancer worldwide. CRC mortality is increasing in Iran. In the current study, we aimed to investigate association between rs11614913 polymorphism of the miR-196-a2 gene and CRC.
Materials and Methods
In this case-control study, we assessed association of the rs11614913 polymorphism in 194 patients with CRC (case) and 286 healthy individuals (control). The expectation-maximization (EM) algorithm method was used to adjust deviation from Hardy-Weinberg equilibrium (HWE).
Results
There was no significant difference between genotypic frequencies of rs11614913 polymorphism in the control and case groups. Genotypic frequencies differed in the adjusted and unadjusted deviations from the HWE. Analysis of unadjusted and adjusted independent variables showed that age, sex, alcohol consumption, and drug use were statistically significant.
Conclusion
Our findings showed that rs11614913 polymorphism was not associated with CRC risk. Deviation from HWE affected the results. It is recommended to perform further studies to establish HWE. Ignoring the equilibrium can cause in consistencies in the results of studies.
کلیدواژه‌های انگلیسی مقاله Association, Colorectal cancer, equilibrium, Gene Polymorphim
نویسندگان مقاله Ali Reza Soltanian |
.Department of Biostatistics, School of Public Health, Hamadan University of Medical Sciences, Hamadan, Iran;.Modeling of Noncommunicable Diseases Research Center, Hamadan University of Medical Sciences, Hamadan, Iran

Bistoon Hosseini |
.Kermanshah Province Electricity Distribution Company, Kermanshah, Iran

Hossein Mahjub |
.Department of Biostatistics, School of Public Health, Hamadan University of Medical Sciences, Hamadan, Iran;4.Research Center for Health Center, Hamadan University of Medical Sciences, Hamadan, Iran

Fatemeh Bahreini |
5.Department of Molecular Medicine and Genetics, Faculty of Medicine, Hamadan University of Medical Sciences, Hamadan, Iran

Nazemalhosseini Mojarad Ehsan |
6.Gastrointestinal (GI) Cancer Department, Gastroenterology and Liver Diseases Research Center, Research Institute for Gastroenterology and Liver Diseases, Shahid Beheshti University of Medical Sciences, Tehran, Iran

Mohammad Ebrahim Ghaffari |
.Department of Biostatistics, School of Public Health, Hamadan University of Medical Sciences, Hamadan, Iran

نشانی اینترنتی https://www.celljournal.org/article_250716_221e4fc45c866fdd468e5a563fad0f6c.pdf
فایل مقاله فایلی برای مقاله ذخیره نشده است
کد مقاله (doi)
زبان مقاله منتشر شده en
موضوعات مقاله منتشر شده
نوع مقاله منتشر شده
برگشت به: صفحه اول پایگاه   |   نسخه مرتبط   |   نشریه مرتبط   |   فهرست نشریات