این سایت در حال حاضر پشتیبانی نمی شود و امکان دارد داده های نشریات بروز نباشند
Cell Journal، جلد ۲۳، شماره ۱، صفحات ۱۴-۲۰
عنوان فارسی
چکیده فارسی مقاله
کلیدواژه‌های فارسی مقاله
عنوان انگلیسی Correlation of sPD1 with Procalcitonin and C-Reactive Protein Levels in Patients with Sepsis
چکیده انگلیسی مقاله Objective
Sepsis results from dysregulated host responses to infection, and it is a major cause of mortality in the world. Co-inhibitory molecules, such as PD-1, play a critical role in this process. Considering the lack of information on the relation between sPD1 and sepsis, the present study aimed to examine the sPD1 level in septic patients and evaluate its correlation with procalcitonin (PCT) and C-reactive protein (CRP) levels.
Materials and Methods
This descriptive cross-sectional study consisted of three groups, including septic patients (n=15), suspected of sepsis (n=15), and healthy subjects (n=15). White blood cells (WBCs) and platelet (PLT) counts are evaluated. The serum levels of CRP, PCT, and sPD1 were measured by immunoturbidimetric assay, electro- chemiluminescence technology, and the enzyme-linked immunosorbent assay (ELISA), respectively.
Results
Our study indicated that there was a significant difference in WBC and PLT counts between the septic group compared to suspected and control groups (P < 0.001, P < 0.01, respectively). The CRP level was significantly higher in septic compared to suspected and control groups (P < 0.001). There was also a significant difference between the PCT level in septic and suspected groups in comparison with the controls (P < 0.001, P < 0.01). The sPD1 level was significantly higher in septic patients compared to suspected and control groups (P < 0.001). In septic patients, sPD1 levels were correlated positively with the CRP and PCT levels.
Conclusion
Overall, sPD1 correlation with inflammatory markers, might propose it as a potential biomarker to sepsis diagnosis. However, the clinical application of serum sPD-1 testing in patients with sepsis requires further investigation.
کلیدواژه‌های انگلیسی مقاله c, Reactive Protein, Procalcitonin, Sepsis, sPD1
نویسندگان مقاله Zahra Bakhshiani |
Department of Immunology, Faculty of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran

Saloomeh Fouladi |
Department of Immunology, Faculty of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran

Samaneh Mohammadzadeh |
Poursina Hakim Digestive Diseases Research Center, Isfahan University of Medical Scineces, Isfahan, Iran

Nahid Eskandari |
Department of Immunology, Faculty of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran;Applied Physiology Research Center, Isfahan University of Medical Sciences, Isfahan, Iran

نشانی اینترنتی https://www.celljournal.org/article_250685_5fe606ddaa3e604eb46eb41099596bc6.pdf
فایل مقاله فایلی برای مقاله ذخیره نشده است
کد مقاله (doi)
زبان مقاله منتشر شده en
موضوعات مقاله منتشر شده
نوع مقاله منتشر شده
برگشت به: صفحه اول پایگاه   |   نسخه مرتبط   |   نشریه مرتبط   |   فهرست نشریات