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Cell Journal، جلد ۲۱، شماره ۳، صفحات ۲۴۳-۲۵۲
عنوان فارسی
چکیده فارسی مقاله
کلیدواژه‌های فارسی مقاله
عنوان انگلیسی Preliminary Findings of Platelet-Rich Plasma-Induced Ameliorative Effect on Polycystic Ovarian Syndrome
چکیده انگلیسی مقاله Objective
Polycystic ovarian syndrome (PCOS) is characterized by hormonal imbalance, oxidative stress and chronic anovulation. The present study was designed to assess ameliorative effect of auto-locating platelet-rich plasma (PRP), as a novel method, for inhibiting PCOS-induced pathogenesis in experimentally-induced hyperandrogenic PCOS.
Materials and Methods
In this experimental study, 30 immature (21 days old) female rats were assigned into five groups, including control (sampled after 30 days with no treatment), 15 and 30 days PCOS-sole-induced as well as 15 and 30 days PRP auto-located PCOS-induced groups. Serum levels of estrogen, progesterone, androstenedione, testosterone, follicle stimulating hormone (FSH), luteinizing hormone (LH), ovarian total antioxidant capacity (TAC), malondialdehyde (MDA), glutathione peroxidase (GSH-px) and superoxide dismutase (SOD) were evaluated. Expression of estrogen receptor α (Erα), β (Erβ) and c-Myc were assessed. Finally, the numbers of intact follicles per ovary and mRNA damage ratio were analyzed.
Results
PRP groups significantly (P < 0.05) decreased serum levels of FSH, LH, testosterone and androstenedione and remarkably (P < 0.05) increased estrogen and progesterone syntheses versus PCOS-sole groups. The PRP auto-located animals exhibited increased TAC, GSH-px and SOD levels, while they showed diminished MDA content (P < 0.05) versus PCOS-sole groups. The PRP auto-located groups exhibited an elevated expression of Erα and Erβ versus PCOS-sole groups. Moreover, PRP groups significantly (P < 0.05) decreased c-Myc expression and mRNA damage compared to PCOS-sole groups, and remarkably improved follicular growth.
Conclusion
PRP is able to regulate hormonal interaction, improve the ovarian antioxidant potential as well as folliculogenesis and its auto-location could be considered as a novel method to prevent/ameliorate PCOS-induced pathogenesis.
کلیدواژه‌های انگلیسی مقاله Folliculogenesis, Oxidative stress, Platelet, Rich Plasma, Polycystic ovarian syndrome, Rat
نویسندگان مقاله Samira Seyyed Anvari |
Department of Biology, Collage of Post Graduate, Ahar Islamic Azad University, Ahar, Iran

Gholamreza Dehgan |
Department of Biochemistry, Faculty of Natural Science, University of Tabriz, Tabriz, Iran

Mazdak Razi |
Department of Basic Science, Faculty of Veterinary Medicine, Urmia University, Urmia, Iran

نشانی اینترنتی https://www.celljournal.org/article_250585_2ed00a209bed9fdf62b77f7dcb5b6381.pdf
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