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Cell Journal، جلد ۲۱، شماره ۳، صفحات ۳۵۰-۳۵۶
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عنوان انگلیسی Mitochondrial Polymorphisms, in The D-Loop Area, Are Associated with Brain Tumors
چکیده انگلیسی مقاله Objective
This study was carried out to evaluate the relationship between mtDNA D-loop variations and the pathogenesis of a brain tumor.
Materials and Methods
In this experimental study, 25 specimens of brain tumor tissue with their adjacent tissues from patients and 454 blood samples from different ethnic groups of the Iranian population, as the control group, were analysed by the polymerase chain reaction (PCR)-sequencing method.
Results
Thirty-six variations of the D-loop area were observed in brain tumor tissues as well as the adjacent normal tissues. A significant difference of A750G (P=0.046), T15936C (P=0.013), C15884G (P=0.013), C16069T (P=0.049), T16126C (P=0.006), C16186T (P=0.022), T16189C (P=0.041), C16193T (P=0.045), C16223T (P=0.001), T16224C (P=0.013), C16234T (P=0.013), G16274A (P=0.009), T16311C (P=0.038), C16327T (P=0.045), C16355T (P=0.003), T16362C (P=0.006), G16384A (P=0.042), G16392A (P=0.013), G16394A (P=0.013), and G16477A (P=0.013) variants was found between the patients and the controls.
Conclusion
The results indicated individuals with C16069T [odds ratio (OR): 2.048], T16126C (OR: 2.226), C16186T (OR: 3.586), G16274A (OR: 4.831), C16355T (OR: 7.322), and T16362C (OR: 6.682) variants with an OR more than one are probably associated with a brain tumor. However, given the multifactorial nature of cancer, more investigation needs to be done to confirm this association.
کلیدواژه‌های انگلیسی مقاله Brain tumor, d, Loop, Mitochondrial DNA
نویسندگان مقاله Donya Altafi |
Molecular Biology Department, NourDanesh Institute of Higher Education, Esfahan, Iran

Soha Sadeghi |
Molecular Biology Department, NourDanesh Institute of Higher Education, Esfahan, Iran

Hamed Hojatian |
Molecular Biology Department, NourDanesh Institute of Higher Education, Esfahan, Iran

Maryam Torabi Afra |
Molecular Biology Department, NourDanesh Institute of Higher Education, Esfahan, Iran

Safoura Pakizeh Kar |
Department of Biology, International University of Guilan, Guilan, Iran

Mojtaba Gorji |
Department of Hematology and Oncology, Lorestan Medical University, Lorestan, Iran

نشانی اینترنتی https://www.celljournal.org/article_250598_21654d54dcf0f7eebd1d0ffe3b2254a7.pdf
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