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Cell Journal، جلد ۱۹، شماره ۱، صفحات ۱۵۹-۱۶۵
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عنوان انگلیسی Percutaneous Autologous Bone Marrow-Derived Mesenchymal Stromal Cell Implantation Is Safe for Reconstruction of Human Lower Limb Long Bone Atrophic Non:union:
چکیده انگلیسی مقاله Objective
Non:union: is defined as a minimum of a 9-month period of time since an injury with no visibly progressive signs of healing for 3 months. Recent studies show that application of mesenchymal stromal cells (MSCs) in the laboratory setting is effective for bone regeneration. Animal studies have shown that MSCs can be used to treat non:union:s. For the first time in an Iranian population, the present study investigated the safety of MSC implantation to treat human lower limb long bone non:union:.
Materials and Methods
It is a prospective clinical trial for evaluating the safety of using autologus bone marrow derived mesenchymal stromal cells for treating non:union:. Orthopedic surgeons evaluated 12 patients with lower limb long bone non:union: for participation in this study. From these, 5 complied with the eligibility criteria and received MSCs. Under fluoroscopic guidance, patients received a one-time implantation of 20-50×106 MSCs into the non:union: site. All patients were followed by anterior-posterior and lateral X-rays from the affected limb, in addition to hematological, biochemical, and serological laboratory tests obtained before and 1, 3, 6, and 12 months after the implantation. Possible adverse effects that included local or systemic, serious or non-serious, and related or unrelated effects were recorded during this time period.
Results
From a safety perspective, all patients tolerated the MSCs implantation during the 12 months of the trial. Three patients had evidence of bony :union: based on the after implantation Xrays.
Conclusion
The results have suggested that implantation of bone marrow-derived MSCs is a safe treatment for non:union:. A double-blind, controlled clinical trial is required to assess the efficacy of this treatment (Registration Number: NCT01206179).
کلیدواژه‌های انگلیسی مقاله Non:union:, Mesenchymal Stromal Cells, Autologous, Bone marrow
نویسندگان مقاله Mohsen Emadedin |


Narges Labibzadeh |


Roghayeh Fazeli |


Fatemeh Mohseni |


Seyedeh Esmat Hosseini |


Reza Moghadasali |


Soura Mardpour |


Vajiheh Azimian |


Alireza Goodarzi |


Maede Ghorbani Liastani |


Ali Mirazimi Bafghi |


Mohamadreza Baghaban Eslaminejad |


Nasser Aghdami |


نشانی اینترنتی https://www.celljournal.org/article_250422_43474497abe063afb49bf96accfd32bd.pdf
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