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Cell Journal، جلد ۱۸، شماره ۳، صفحات ۳۰۲-۳۰۹
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عنوان انگلیسی Mesenchymal Stromal Cells Implantation in Combination with Platelet Lysate Product Is Safe for Reconstruction of Human Long Bone Non:union:
چکیده انگلیسی مقاله Objective
Non:union: is defined as a minimum of 9 months since injury without any visible progressive signs of healing for 3 months. Recent literature has shown that the application of mesenchymal stromal cells is safe, in vitro and in vivo, for treating long bone non:union:. The present study was performed to investigate the safety of mesenchymal stromal cell (MSC) implantation in combination with platelet lysate (PL) product for treating human long bone non:union:.
Materials and Methods
In this case series clinical trial, orthopedic surgeons visited eighteen patients with long bone non:union:, of whom 7 complied with the eligibility criteria. These patients received mesenchymal stromal cells (20 million cells implanted once into the non:union: site using a fluoroscopic guide) in combination with PL product. For evaluation of the effects of this intervention all the patients were followed up by taking anterior-posterior and lateral X-rays of the affected limb before and 1, 3, 6, and 12 months after the implantation. All side effects (local or systemic, serious or non-serious, related or unrelated) were observed during this time period.
Results
From a safety perspective the MSC implantation in combination with PL was very well tolerated during the 12 months of the trial. Four patients were healed; based on the control Xray evidence, bony :union: had occurred.
Conclusion
Results from the present study suggest that the implantation of bone marrow-derived MSCs in combination with PL is safe for the treatment of non:union:. A double blind, controlled clinical trial is required to assess the efficacy of this treatment (Registration Number: NCT01206179).
کلیدواژه‌های انگلیسی مقاله Fractures Ununited, Mesenchymal Stromal Cells, Platelet Lysate
نویسندگان مقاله Narges Labibzadeh |


Mohsen Emadedin |


Roghayeh Fazeli |


Fatemeh Mohseni |


Seyedeh Esmat Hosseini |


Reza Moghadasali |


Soura Mardpour |


Vajiheh Azimian |


Maede Ghorbani Liastani |


Ali Mirazimi Bafghi |


Mohamadreza Baghaban Eslaminejad |


Nasser Aghdami |


نشانی اینترنتی https://www.celljournal.org/article_250374_99b21c068e09ad3e6a572fe683fe6539.pdf
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