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International Journal of Fertility and Sterility، جلد ۱۷، شماره ۴، صفحات ۲۱۸-۲۲۵
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عنوان انگلیسی Functional Roles of lncRNAs in Recurrent Pregnancy Loss: A Review Study
چکیده انگلیسی مقاله Recurrent pregnancy loss (RPL) or recurrent miscarriage is the failure of pregnancy before 20-24 weeks that influences
around 2-5% of couples. Several genetic, immunological, environmental and physical factors may influence
RPL. Although various traditional methods have been used to treat post-implantation failures, identifying the mechanisms
underlying RPL may improve an effective treatment. Recent evidence suggested that gene expression alterations
presented essential roles in the occurrence of RPL. It has been found that long non-coding RNAs (lncRNAs) play
functional roles in pregnancy pathologies, such as recurrent miscarriage. lncRNAs can function as dynamic scaffolds,
modulate chromatin function, guide and bind to microRNAs (miRNAs) or transcription factors. lncRNAs, by targeting
various miRNAs and mRNAs, play essential roles in the progression or suppression of RPL. Therefore, targeting
lncRNAs and their downstream targets might be a suitable strategy for diagnosis and treatment of RPL. In this review,
we summarized emerging roles of several lncRNAs in stimulation or suppression of RPL.
کلیدواژه‌های انگلیسی مقاله Diagnosis, implantation, lncRNAs, miRNAs, recurrent miscarriage
نویسندگان مقاله Shirin Azizidoost |
Atherosclerosis Research Center, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran

Mahrokh Abouali Gale Dari |
Department of Obstetrics and Gynecology, School of Medicine, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran

Farhoodeh Ghaedrahmati |
Department of Immunology, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran

Zahra Razani |
Department of Animal Physiology, Faculty of Veterinary Medicine, Ferdowsi University of Mashhad, Mashhad, Iran

Mona Keivan |
Fertility and Infertility Research Center, Kermanshah University of Medical Sciences, Kermanshah, Iran

Razieh Mohammad Jafari |
Department of Obstetrics and Gynecology, Fertility, Infertility and Perinatology Research Center, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran

Mahin Najafian |
Department of Obstetrics and Gynecology, Fertility, Infertility and Perinatology Research Center, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran

Maryam Farzaneh |
Fertility, Infertility and Perinatology Research Center, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran

نشانی اینترنتی https://www.ijfs.ir/article_700749_414c745959e4545fd4ae9d5a46a940a1.pdf
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