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International Journal of Fertility and Sterility، جلد ۱۷، شماره ۴، صفحات ۲۳۶-۲۴۱
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عنوان انگلیسی Gene Expression Levels of CSF-1 and CSF-1R Endometrial under The Influence of Prolactin Level in Unexplained Miscarriage: A Case-Control Study
چکیده انگلیسی مقاله Background: Hormones such as prolactin, by influencing expression of the endometrial genes, play a pivotal
role in embryo implantation and development. The present study aimed to evaluate serum level of prolactin and
its effect on altering expression level of colony-stimulating factor-1 (CSF-1) and colony-stimulating factor-1 receptor
(CSF-1R) genes in endometrial tissue during in vitro fertilization (IVF) pregnancy in the infertile women
and recurrent pregnancy loss (RPL), compared to fertile women, who lost their pregnancies at gestational age
<20 weeks.
Materials and Methods: In this case-control study, 40 infertile women, 40 IVF pregnant women with RPL and 40
fertile women who lost their pregnancies at <20 weeks of gestation for unknown reasons were selected. Prolactin
serum level was assessed using ELISA technique and expression of CSF-1 and CSF-1R genes was determined in
endometrial tissue, using quantitative reverse transcription polymerase chain reaction (qRT-PCR).
Results: Mean prolactin level of the infertile group was 24.38 ± 1.43 ng/mL and it had statistically significant
relationship with the fertile group (P<0.001). Expression level of the CSF-1 and CSF-1R genes were higher in the
fertile than infertile groups by 2.88 times (P<0.0001) and 2.64 times (P<0.0001), while it was respectively 2.28
(P<0.0001) and 1.69 (P<0.0001) times higher compared to the RPL group. Risk factors for pregnancy loss, such
as aging, increased body mass index (BMI), smoking and diabetes caused decreasing changes in gene expression
(CSF-1 and CSF-1R) and the differences were statistically significant, except in the infertile group.
Conclusion: The present study showed a significant relationship of CSF-1 and CSF-1R expression levels with pregnancy
loss. Risk factors such as aging, obesity, smoking and diabetes decreased both genes expression levels.
کلیدواژه‌های انگلیسی مقاله genes, infertility, Miscarriage, Prolactin, Recurrent Pregnancy Loss
نویسندگان مقاله Zahra Sadeghi Jam |
Department of Biology, Roudehen Branch, Islamic Azad University, Roudehen, Iran

Zahra Tahmasebi Fard |
Department of Biology, Roudehen Branch, Islamic Azad University, Roudehen, Iran

نشانی اینترنتی https://www.ijfs.ir/article_705335_76373d4073a766660c46087e9220009e.pdf
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