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International Journal of Fertility and Sterility، جلد ۱۷، شماره ۴، صفحات ۲۶۸-۲۷۵
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عنوان انگلیسی Forskolin Improves Male Reproductive Complications Caused by Hyperglycemia in Type 2 Diabetic Rats
چکیده انگلیسی مقاله Background: In many diabetic patients, spermatogenesis complications are frequent causing infertility problems.
This study aimed to demonstrate the effect of Forskolin on male reproductive dysfunction caused by type 2 diabetes.
Materials and Methods: In this experimental study, type 2 diabetes was induced by a high-fat diet (HFD) for one
month and then a low single dose injection (35 mg/kg) of streptozotocin (STZ) in Wistar rats. After 72 hours, rats with
more than 200 mg/dl of blood glucose were considered type 2 diabetic rats. Forty rats (200-250 g) were divided into
four groups (n=10) including group 1 (G1): rats with normal diet and buffer citrate (STZ solvent) injection, group 2
(G2): control type 2 diabetic rats with HFD and STZ injection, group 3 (G3): type 2 diabetic rats received phosphate
buffer saline (PBS) as Forskolin solvent, and group 4 (G4): Forskolin treated diabetic rats (10 mg/kg) for 1 month.
Results: In comparison to control group, in diabetic groups (G2 and G3) some parameters are increased significantly:
The blood glucose (P=0.00078), testicular malondialdehyde (MDA) level and body weight (P=0.00009) and Bax
gene expression (P=0.00007). Unlike, some parameters are decreased significantly: The serum level of testosterone
(P=0.0009), testicular superoxide dismutase (SOD, P=0.00007) and glutathione peroxidase (GPX) levels (P=0.00008),
sperm concentration (P=0.00008), motility (P=0.00009), normal morphological sperm (P=0.00008) and Bcl-2 gene
expression (P=0.00009). However, in Forskolin treated group (G4) the parameters stayed close to control values that
was significantly (P=0.00007) higher than in G2 and G3 groups. Therefore, treatment with Forskolin significantly
improved these abnormal changes in Forskolin-treated group.
Conclusion: Our study demonstrates that Forskolin is an effective antidiabetic agent, which significantly improves
sperm concentration, testosterone levels, and antioxidant activity in diabetic rats.
کلیدواژه‌های انگلیسی مقاله FORSKOLIN, Male infertility, Oxidative stress, testicular dysfunction, type 2 diabetes
نویسندگان مقاله Mehran Naghibi |
Drug Applied Research Center, Tabriz University of Medical Sciences, Tabriz, Iran

Hamid Tayefi Nasrabadi |
Department of Anatomical Sciences, Faculty of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran

Jafar Soleimani Rad |
Department of Anatomical Sciences, Faculty of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran

Alireza Garjani |
Department of Pharmacology, Faculty of Pharmacy, Tabriz University of Medical Sciences, Tabriz, Iran

Mohammad Sadegh Gholami Farashah |
Department of Anatomical Sciences, Faculty of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran

Daryoush Mohammadnejad |
Drug Applied Research Center, Tabriz University of Medical Sciences, Tabriz, Iran

نشانی اینترنتی https://www.ijfs.ir/article_253293_b736f6619d34b9118992d9de83833288.pdf
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