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International Journal of Fertility and Sterility، جلد ۱۷، شماره ۳، صفحات ۲۰۱-۲۰۷
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عنوان انگلیسی Effects of Date Palm Pollen Supplementations on The Expression of PRDX1 and PRDX6 Genes in Infertile Men: A Controlled Clinical Trial
چکیده انگلیسی مقاله Background: Accumulating evidences suggest that date palm pollen (DPP) induces antioxidant activity and improves
semen parameters in male rats. However, there is a few scientific evidences in support of the DPP effects on human
male fertility. Hence, the effect of oral consumption of DPP on sperm parameters and expression pattern of Peroxiredoxin-
1 (PRDX1) and Peroxiredoxin-6 (PRDX6) genes was evaluated in men with infertility.
Materials and Methods: The current controlled clinical trial included 40 men with infertility (DPP group) and 10 normospermic
fertile men as controls. The DPP group received gelatinous capsules of DPP (400 mg/kg) for 74 days. Semen
sampling was done before and after treatment in the both groups. Semen analysis and 8-isoprostane concentration assessments
were performed by computer-assisted sperm analysis and ELISA methods, respectively. Quantitative reverse transcription
polymerase chain reaction (qRT-PCR) assays were employed to explore expression of PRDX1 and PRDX6 genes.
Results: DPP consumption significantly improved semen volume (P=0.030), count (P<0.001) and morphology of
sperm (P=0.023). Concentration of 8-isoprostane was significantly decreased after intervention in the DPP group
(P<0.001). DPP consumption led to a significant elevation in the expression of PRDX1 and PRDX6 genes (P<0.001).
Elevated gene expression of PRDX6 and PRDX1 was positively correlated with improved parameters of sperm including
count, volume, motility and morphology.
Conclusion: Taken together, DPP seems to promote sperm quality through a decrease in reactive oxygen species
(ROS) by increasing expression of antioxidant genes. Further large-scale studies are required to challenge this hypothesis
(registration number: IRCT2015021221014N2)
کلیدواژه‌های انگلیسی مقاله 8-isoprostane, Male infertility, PRDX1, PRDX6
نویسندگان مقاله Ali Mohammad Falahati |
Department of Medical Genetics, Faculty of Medicine, Hormozgan University of Medical Sciences, Bandar Abbas, Iran

Soghra Fallahi |
Hormozgan Institute of Health, Hormozgan University of Medical Sciences, Bandar Abbas, Iran

Zeinab Allamehzadeh |
Medical Genetics and Prenatal Diagnostic Lab, Shahid Mohammadi Hospital, Hormozgan University of Medical Sciences, Bandar Abbas, Iran

Maliheh Izadi Raieni |
Medical Genetics and Prenatal Diagnostic Lab, Shahid Mohammadi Hospital, Hormozgan University of Medical Sciences, Bandar Abbas, Iran

Kianoosh Malekzadeh |
Department of Medical Genetics, Faculty of Medicine, Hormozgan University of Medical Sciences, Bandar Abbas, Iran

نشانی اینترنتی https://www.ijfs.ir/article_697936_f148664a2d0a814259eeab1087c27ab1.pdf
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