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International Journal of Fertility and Sterility، جلد ۱۷، شماره ۲، صفحات ۸۵-۹۱
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عنوان انگلیسی microRNAs as A Biomarker to Predict Embryo Quality Assessment in In Vitro Fertilization
چکیده انگلیسی مقاله Embryo selection for in vitro fertilization (IVF) is an effort to increase the success rate of embryo implantation. Factors influencing the success of embryo implantation include embryo quality, endometrial receptivity, embryo characteristics, and maternal interactions. Some molecules have been found to influence these factors, but their regulatory mechanisms are unclear. MicroRNAs (miRNAs) are reported to play an essential role in the embryo implantation process. miRNAs are small non-coding RNAs consisting of only 20 nucleotides that play an essential role in the stability of gene expression regulation. Previous studies have reported that miRNAs have many roles and are released by cells into the extracellular environment for intracellular communication. In addition, miRNAs can provide information related to physiological and pathological conditions. These findings encourage research development in determining the quality of embryos in IVF to increase the implantation success rate. Moreover, miRNAs can provide an overview of embryo-maternal communication and potentially be noninvasive biological markers of embryo quality, which could increase assessment accuracy while reducing mechanical damage to the embryo itself. This review article summarizes the involvement of extracellular miRNAs and the potential applications of miRNAs in IVF.
کلیدواژه‌های انگلیسی مقاله Blastocyst, embryo, In vitro fertilization, miRNAs, Oocyte
نویسندگان مقاله Kresna Mutia |
Universitas IndonesiaMaster Program of Biology, Department of Biology, Faculty of Mathematics and Natural Science, Universitas Indonesia, Depok, Indonesia

Budi Wiweko |
Human Reproduction, Infertility and Family Planning Research Center, Indonesian Medical Education and Research Institute, Faculty of Medicine, Universitas Indonesia Jakarta, Jakarta, Indonesia

Abinawanto Abinawanto |
Cellular and Molecular Mechanisms in Biological System (CEMBIOS) Research Group, Department of Biology, Faculty of Mathematics and Natural Sciences, Universitas Indonesia, Depok, Indonesia

Astari Dwiranti |
Cellular and Molecular Mechanisms in Biological System (CEMBIOS) Research Group, Department of Biology, Faculty of Mathematics and Natural Sciences, Universitas Indonesia, Depok, Indonesia

Anom Bowolaksono |
Human Reproduction, Infertility and Family Planning Research Center, Indonesian Medical Education and Research Institute, Faculty of Medicine, Universitas Indonesia Jakarta, Jakarta, Indonesia

نشانی اینترنتی https://www.ijfs.ir/article_255170_b2860a61d14fb1b9d6412bc279554080.pdf
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