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International Journal of Fertility and Sterility، جلد ۱۵، شماره ۳، صفحات ۱۹۷-۲۰۱
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عنوان انگلیسی Follicular Fluid Zinc Level and Oocyte Maturity and Embryo Quality in Women with Polycystic Ovary Syndrome
چکیده انگلیسی مقاله Background:
Polycystic ovary syndrome (PCOS) is considered to be one of the most common endocrine disorders in women of reproductive age. Zinc, a vital trace element in the body, plays a key role in maintaining health, especially due to its antioxidant role. On the other hand, lack of antioxidants and oxidative stress can adversely affect oocytes quality and consequently fertility rate. The available studiesthat report the effect of follicular fluid (FF) zinc in terms of the number and quality of the oocytes in infertile women with PCOS, are few and not consistent. We decided to
investigate this issue.
Materials and Methods:
In this cross-sectional study, from the women with PCOS referring to Omolbanin Hospital, Dezful, Iran (February to December 2019), a total of 90 samples (follicular fluid, oocytes, and embryos) were collected from those who had undergone in vitro fertilization (IVF). To measure zinc level in follicular fluid, high performance liquid chromatograpy (HPLC) was utilized. Also, oocytes maturity and embryos quality evaluation was performed using inverted optical microscopy. One-way ANOVA and Fisher’s least significant difference (LSD) were used for data analysis.
Results:
The amount of FF zinc was not associated with any significant differences in the number of oocytes and metaphase I (MI) and germinal vesicle (GV) oocytes, but a significant decrease was observed in the number of metaphase II (MII) oocytes at zinc values lessthan 35 μg/dL. The FF zinc levels lessthan 35 μg/dL were also significantlyassociated with decreased embryo quality.
Conclusion:
A significant relationship was found between the level of FF zinc and the quality and the number of oocytes taken from the ovaries of infertile patients with PCOS history who were candidates for IVF treatment as well as the number of high quality embryos.
کلیدواژه‌های انگلیسی مقاله embryo, Oocyte, Polycys tic Ovary Syndrome, Zinc
نویسندگان مقاله Sima Janati |
Department of Obstetrics and Gynecology, School of Medicine, Research and Clinical Center for Infertility, Dezful University of Medical Sciences, Dezful, Iran

Mohammad Amin Behmanesh |
Department of Histology, School of Medicine, Dezful University of Medical Sciences, Dezful, Iran

Hosein Najafzadehvarzi |
Department of Pharmacology, Faculty of Medicine, Babol University of Medical Sciences, Babol, Iran

Zahra Akhundzadeh |
School of Medicine, Dezful University of Medical Sciences, Dezful, Iran

Seyyedeh Mahsa Poormoosavi |
Department of Histology, School of Medicine, Research and Clinical Center for Infertility, Dezful University of Medical Sciences, Dezful, Iran

نشانی اینترنتی https://www.ijfs.ir/article_241407_ae2eb551d0cb53f64ea18625eb662ccc.pdf
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