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International Journal of Fertility and Sterility، جلد ۱۴، شماره ۲، صفحات ۷۹-۸۳
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عنوان انگلیسی Male Equivalent Polycystic Ovarian Syndrome: Hormonal, Metabolic and Clinical Aspects
چکیده انگلیسی مقاله Recent studies identified the presence of a male polycystic ovarian syndrome (PCOS), which mainly affects men whose female relatives are afflicted with PCOS, caused by genes responsible for the susceptibility of this syndrome in women. Similar hormonal, metabolic, and clinical alterations occurring in PCOS women have also been reported in their male relatives, suggesting a association between the male and female forms of the syndrome. Although the remarkable clinical manifestation of the male equivalent PCOS is diagnosed by the early-onset androgenetic alopecia, characterized by hair recession, pronounced hypertrichosis, insulin resistance, biochemical and hormonal abnormalities, the hormonal/metabolic profile is still controversial. Men affected by early-onset androgenetic alopecia (AGA) are at risk of developing hyperinsulinemia, insulin-resistance, dyslipidaemia, and cardiovascular diseases. However, there is no consensus on the association of male equivalent PCOS with hypertension and obesity. Moreover, reduced levels of sex hormone-binding globulin have been detected in these male patients, accompanied by increased free androgens. Conversely, literature reported lower concentrations of testosterone in male equivalent PCOS when compared with the normal range, indicating a crucial role for the conversion of cortical androgens. Finally, further studies are warranted to investigate a possible link among AGA, metabolic/hormonal alterations, and acne. Our study assessed the hormo- nal, metabolic and clinical aspects of male equivalent PCOS syndrome reported in the literature to evaluate similar and divergent elements involved in the female version of the syndrome.
کلیدواژه‌های انگلیسی مقاله Androgenetic Alopecia, Insulin resistance, Polycystic ovarian syndrome
نویسندگان مقاله Federica Di Guardo |
Department of General Surgery and Medical Surgical Specialties, University of Catania, Catania, Italy

Lilliana Ciotta |
Department of General Surgery and Medical Surgical Specialties, University of Catania, Catania, Italy

Morena Monteleone |
Department of General Surgery and Medical Surgical Specialties, University of Catania, Catania, Italy

Marco Palumbo |
Department of General Surgery and Medical Surgical Specialties, University of Catania, Catania, Italy

نشانی اینترنتی https://www.ijfs.ir/article_45585_12a885adb13f008c9332093f6b21ce25.pdf
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