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International Journal of Fertility and Sterility، جلد ۱۴، شماره ۲، صفحات ۱۵۴-۱۵۸
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عنوان انگلیسی Which One Is More Prominent in Recurrent Hydatidiform Mole, Ovum or Sperm?
چکیده انگلیسی مقاله Recurrent hydatidiform mole is defined as episodes of two molar pregnancies in a female. Often, complete moles only derive androgenic nuclear genome. We described two cases with repeated molar pregnancies attempted to prevent future episodes by performing intracytoplasmic sperm injection (ICSI) and preimplantation genetic diagnosis (PGD) to assess genetic disorders. The first patient had previously six complete molar pregnancies and advised to carry out ICSI with ovum donation to achieve a normal pregnancy. The second case had previously five molar pregnancies and no XY embryos from the ICSI/PGD process. We had to (at the insistence of the patient) transfer XX embryos in this patient which resulted in a complete hydatidiform mole (CHM). Hence, available data based on our patients and previous studies demonstrated that oocyte might play a critical role in the pathophysiology of recurrent hydatidiform mole, while it has not been often considered.
کلیدواژه‌های انگلیسی مقاله Hydatidiform Mole, Intracytoplasmic Sperm Injections, Ovum Donation, Preimplantation Genetic Diagnosis
نویسندگان مقاله Maryam Hafezi |
Department of Endocrinology and Female Infertility, Reproductive Biomedicine Research Center, Royan Institute for Reproductive Biomedicine, ACECR, Tehran, Iran.

Zahra Chekini |
Department of Endocrinology and Female Infertility, Reproductive Biomedicine Research Center, Royan Institute for Reproductive Biomedicine, ACECR, Tehran, Iran.

Mohammadreza Zamanian |
Department of Genetics, Reproductive Biomedicine Research Center , Royan Institute for Reproductive Biomedicine, ACECR, Tehran , Iran.

نشانی اینترنتی https://www.ijfs.ir/article_45596_0a89d12408ea89a3a90587a1263baabc.pdf
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