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International Journal of Fertility and Sterility، جلد ۱۴، شماره ۱، صفحات ۲۳-۲۶
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عنوان انگلیسی Effect of Single-Dose Methotrexate Treatment on Ovarian Reserve in Women with Ectopic Pregnancy Undergoing Infertility Treatment: A Single-Center Experience
چکیده انگلیسی مقاله Background
The aim of this study was evaluation of the impact of single-dose methotrexate (MTX) treatment on ovarian reserve in women with ectopic pregnancy (EP) undergoing infertility treatment in Iranian population.
Materials and Methods
This prospective cohort study was done between March 2015 and March 2017 in Tehran General Women Hospital, Tehran, Iran. We enrolled 20 patients with EP who conceived during infertility treatment and received a single-dose MTX (50 mg/m2) intramuscularly. Serum anti-Mullerian hormone (AMH), 17 beta-estra diol (E2), luteinizing hormone (LH), follicle-stimulating hormone (FSH) and antral follicle count (AFC) on transvaginal ultrasonography, were evaluated before and 8 weeks after administration of MTX.
Results
AMH did not significantly vary after the administration of MTX, compared to before treatment value (P=0.36). FSH, E2 and AFC changes were not statistically significant, while increment of LH was significant (P=0.02).
Conclusion
Results indicated that single-dose MTX treatment did not reduce ovarian reserve in women with EP. Further randomized controlled clinical trial studies with larger sample sizes, by using multiple dosages of MTX, and with long-term follow up are suggested to be done.
کلیدواژه‌های انگلیسی مقاله Anti, Mullerian Hormone, Assisted Reproductive Techniques, Ectopic pregnancy, Methotrexate, OVARIAN RESERVE
نویسندگان مقاله Mahboobeh Shirazi |
Maternal, Fetal and Neonatal Research Center, Tehran, Iran;Breast Feeding Research Center, Tehran University of Medical Sciences, Tehran, Iran

Parichehr Pooransari |
Shohada Hospital, Shahid Beheshti University of Medical Sciences, Tehran, Iran

Neda Hajiha |
Breast Feeding Research Center, Tehran University of Medical Sciences, Tehran, Iran

Zeinab Shaker |
Maternal, Fetal and Neonatal Research Center, Tehran, Iran

Mohadeseh Ghazi |
Breast Feeding Research Center, Tehran University of Medical Sciences, Tehran, Iran

Fatemeh Davari Tanha |
Maternal, Fetal and Neonatal Research Center, Tehran, Iran

Batool Ghorbani Yekta |
4Young Researchers and Ethics Club, Tehran Medical Science Branch, Islamic Azad University, Tehran, Iran;5Herbal Pharmacology Research Center, Tehran Medical Science Branch, Islamic Azad University, Tehran, Iran

Marjan Ghaemi |
Maternal, Fetal and Neonatal Research Center, Tehran, Iran;6Kamali Hospital, Alborz University of Medical Sciences, Karaj, Iran

نشانی اینترنتی https://www.ijfs.ir/article_45573_7b0f080ce0ee61ec582edaabf1dc7c2e.pdf
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