این سایت در حال حاضر پشتیبانی نمی شود و امکان دارد داده های نشریات بروز نباشند
International Journal of Fertility and Sterility، جلد ۱۱، شماره ۲، صفحات ۶۳-۷۰
عنوان فارسی
چکیده فارسی مقاله
کلیدواژه‌های فارسی مقاله
عنوان انگلیسی Reactive Oxygen Species Generation and Use of Antioxidants during In Vitro Maturation of Oocytes
چکیده انگلیسی مقاله In vitro maturation (IVM) is emerging as a popular technology at the forefront of fertility treatment and preservation. However, standard in vitro culture (IVC) conditions usually increase reactive oxygen species (ROS), which have been implicated as one of the major causes for reduced embryonic development. It is well-known that higher than physiological levels of ROS trigger granulosa cell apoptosis and thereby reduce the transfer of nutrients and survival factors to oocytes, which leads to apoptosis. ROS are neutralized by an elaborate defense system that consists of enzymatic and non-enzymatic antioxidants. The balance between ROS levels and antioxidants within IVM media are important for maintenance of oocytes that develop to the blastocyst stage. The effects of antioxidant supplementation of IVM media have been studied in various mammalian species. Therefore, this article reviews and summarizes the effects of ROS on oocyte quality and the use of antioxidant supplementations for IVM, in addition to its effects on maturation rates and further embryo development.
کلیدواژه‌های انگلیسی مقاله Oxidative stress, Reactive Oxygen Species, Antioxidant, maturation
نویسندگان مقاله Mozafar Khazaei |
Fertility and Infertility Research Center, Kermanshah University of Medical Sciences, Kermanshah, Iran

Faranak Aghaz |
Fertility and Infertility Research Center, Kermanshah University of Medical Sciences, Kermanshah, Iran

نشانی اینترنتی https://www.ijfs.ir/article_45416_0764e820ea499d2f0a726b0341e76b15.pdf
فایل مقاله فایلی برای مقاله ذخیره نشده است
کد مقاله (doi)
زبان مقاله منتشر شده en
موضوعات مقاله منتشر شده
نوع مقاله منتشر شده
برگشت به: صفحه اول پایگاه   |   نسخه مرتبط   |   نشریه مرتبط   |   فهرست نشریات