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International Journal of Fertility and Sterility، جلد ۲، شماره ۴، صفحات ۱۶۵-۱۶۸
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عنوان انگلیسی Flexible Multi-dose GnRH Antagonist versus Long GnRH Agonist Protocol in Poor Responders: A Randomized Controlled Trial
چکیده انگلیسی مقاله Background
To compare a flexible, multi-dose GnRH antagonist protocol with a long GnRH .agonist protocol in poor respo


Materials and methods
A randomized clinical trial of 70 poor responder patients (35 patients in GnRH antagonist protocol and 35 patients in long GnRH agonist protocol) was performed at Royan Institute, Tehran, Iran. Both groups were given a fixed dose of human menopausal gonadotropin HMG) for stimulation and oral contraceptive pre-treatment. Data analyzed by student’s group) .t-test or Chi square test


Results
Stimulation duration, total gonadotrophins consumption, mean numbers of oocytes retrieved, formed embryos, cycle cancellation rate, and clinical pregnancy rate were similar between both groups. Although the miscarriage rate was higher in the agonist protocol group, the rate of .miscarriage was not statistically significant between both gro


Conclusion
A flexible, multi-dose GnRH antagonist protocol appears as effective as the long GnRH agonist protocol in poor responders. More (larger) randomized controlled trials for better .statistical analysis are recommended
کلیدواژه‌های انگلیسی مقاله GnRH Agonist, GnRH Antagonist, IVF, Poor Ovarian Function
نویسندگان مقاله Ensieh Shahrokh Tehraninejad |
Endocrinology and Female Infertility Department, Reproductive Medicine Research Center, Royan Institute, ACECR, Tehran, Iran Faculty of Medicine, Tehran University of Medical Sciences, Tehran, Iran

Azadeh Fazel |
Faculty of Medicine, Tehran University of Medical Sciences, Tehran, Iran

Arash Samiei |
Faculty of Medicine, Tehran University of Medical Sciences, Tehran, Iran

Batool Rashidi |
Vali-e-Asr Reproductive Health Research Center, Imam Khomeini Hospital, Tehran University of Medical Sciences, Tehran, Iran

Kiandokht Kiani |
Endocrinology and Female Infertility Department, Reproductive Medicine Research Center, Royan Institute, ACECR, Tehran, Iran

نشانی اینترنتی https://www.ijfs.ir/article_45728_255d5453cf4af58e8f40701bfafcc16e.pdf
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