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International Journal of Fertility and Sterility، جلد ۱، شماره ۲، صفحات ۸۵-۸۸
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عنوان انگلیسی Evaluation of Protamine Deficiency and DNA Fragmentation in Two Globozoospermia Patients Undergoing ICSI
چکیده انگلیسی مقاله The aim of this report has been evaluating protamine content and DNA integrity of two patients with globozoospermia undergoing Intra Cytoplasmic Sperm Injection (ICSI).
Semen analysis was carried out according to WHO criteria. Protamine deficiency and DNA fragmentation was assessed using Chromomycin A3 and sperm chromatin dispersion assay respectively. ICSI and chemical activation were carried out on inseminated oocyte.
Both cases demonstrated high degrees of protamine deficiency, while one of the cases indicated high level of DNA fragmentation, too. High fertilization rates were achieved in both cases. However, embryo transfer did not lead to implantation or pregnancy.
Artificial oocyte activation overcomes low fertilization rate reported in cases with high level of protamine deficiency. In the present study, failed implantation in one of the cases may be caused by high DNA fragmentation.
کلیدواژه‌های انگلیسی مقاله Globozoospermia, ICSI, Protamine Deficiency, DNA fragmentation
نویسندگان مقاله Mohammad Reza Deemeh |
Isfahan Fertility and Infertility Center

Marziyeh Tavalaee |
Embryology and Andrology Department, Royan Institute

Shahnaz Razavi |
Anatomy Department, School of Medicine, Isfahan University of Medical Science

Mohammad Hossein Nasr-Esfahani |
Isfahan Fertility and Infertility Center

نشانی اینترنتی https://www.ijfs.ir/article_45648_17bcb09e9f2d47747dca011269e44f8d.pdf
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