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Iranian Journal of Basic Medical Sciences، جلد ۲۷، شماره ۱، صفحات ۴۹-۵۶
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عنوان انگلیسی Unacylated ghrelin attenuates acute liver injury and hyperlipidemia via its anti-inflammatory and anti-oxidative activities
چکیده انگلیسی مقاله Objective(s): Liver injury and hyperlipidemia are major issues that have drawn more and more attention in recent years. The present study aimed to investigate the effects of unacylated ghrelin (UAG) on acute liver injury and hyperlipidemia in mice.Materials and Methods: UAG was injected intraperitoneally once a day for three days. Three hours after the last administration, acute liver injury was induced by intraperitoneal injection of carbon tetrachloride (CCl4), and acute hyperlipidemia was induced by intraperitoneal injection of poloxamer 407, respectively. Twenty-four hours later, samples were collected for serum biochemistry analysis, histopathological examination, and Western blotting.Results: In acute liver injury mice, UAG significantly decreased liver index, serum alanine aminotransferase (ALT), aspartate aminotransferase (AST), interleukin-6 (IL-6), and tumor necrosis factor-α (TNF-α), reduced malondialdehyde (MDA) concentration and increased superoxide dismutase(SOD) in liver tissue. NF-kappa B (NF-κB) protein expression in the liver was down-regulated. In acute hyperlipidemia mice, UAG significantly decreased serum total cholesterol (TC), triglyceride (TG), ALT, and AST, as well as hepatic TG levels. Meanwhile, hepatic MDA decreased and SOD increased significantly. Moreover, UAG improved the pathological damage in the liver induced by CCl4 and poloxamer 407, respectively.Conclusion: Intraperitoneal injection of UAG exhibited hepatoprotective and lipid-lowering effects on acute liver injury and hyperlipidemia, which is attributed to its anti-inflammatory and anti-oxidant activities. 
کلیدواژه‌های انگلیسی مقاله Anti-inflammatory, Anti-oxidative, Hyperlipidemia, Intraperitoneal injection, Liver injury, Unacylated ghrelin
نویسندگان مقاله | Yating Gong
Department of Pharmacy, College of Chemical Engineering, Qingdao University of Science and Technology, Qingdao, China


| Beibei Qiu
Department of Pathology, Feicheng Hospital Affiliated to Shandong First Medical University, Qingdao, China


| Haotian Zheng
Department of Pharmacy, College of Chemical Engineering, Qingdao University of Science and Technology, Qingdao, China


| Xiangbo Li
Department of Pharmacy, College of Chemical Engineering, Qingdao University of Science and Technology, Qingdao, China


| Yifan Wang
Department of Pharmacy, College of Chemical Engineering, Qingdao University of Science and Technology, Qingdao, China


| Mengran Wu
Department of Pharmacy, College of Chemical Engineering, Qingdao University of Science and Technology, Qingdao, China


| Meixing Yan
Department of Pharmacy, Qingdao Women and Children’s Hospital, Qingdao, China


| Yanling Gong
Department of Pharmacy College of Chemical Engineering Qingdao University of Science and Technology Qingdao, 266042 China
نشانی اینترنتی https://ijbms.mums.ac.ir/article_23145.html
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