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Iranian Heart Journal، جلد ۲۳، شماره ۲، صفحات ۹۶-۱۰۵
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عنوان انگلیسی Age-Connected Variations of Clinical and Angiographic Profiles and Outcomes in an Urban Population With Acute Coronary Syndrome
چکیده انگلیسی مقاله Background: Acute coronary syndrome (ACS) is a rapidly growing concern, especially among younger urban communities. We aimed to study age-based differences in clinical and angiographic profiles and outcomes in an urban population. Methods: This study recruited 2 independent, equal-sized cohorts of consecutive patients with ACS undergoing coronary angiography: younger and older cohorts (based on an age cutoff point of 35 years). Clinical and angiographic profiles were compared as primary endpoints, and in-hospital and 3-month major adverse cardiovascular events (MACE) were compared between the 2 cohorts as secondary endpoints. Results: Each cohort was composed of 103 patients. The younger cohort, compared with the older cohort, revealed higher overweight (69.9% vs 51.5%), positive family history (12.6% vs 4.9%; P=0.048),  use of gutka (smokeless tobacco) (56.3% vs 14.3%; P=0.017), smoking (41.7% vs 33%; P=0.195), total cholesterol (155.05±46.6 mg/dL vs 140.40±35.6 mg/dL; P=0.012), low-density lipoprotein cholesterol (96.74±41.23 mg/dL vs 84.14±27.25 mg/dL; P=0.010), normal/nonobstructive coronaries (15.5% vs 1.9%; P<0.001), single-vessel disease (60.2% vs 35.0%), type A lesions (36.8% vs 17.8%), left ventricular ejection fraction exceeding 40% (57.3% vs 42.7%; P=0.037), medical treatment only as the management strategy (16.5% vs 2.9%), in-hospital MACE (8.7% vs 12.6%; P=0.0367), and 3-month MACE (4.9% vs 12.6%; P=0.048), respectively. Conclusions: Our younger subjects tended to have higher weight, gutka use, and positive family history than traditional risk factors with a greater frequency of single-vessel disease with type A lesions and normal or nonobstructive disease amenable to medical treatment only. (Iranian Heart Journal 2022; 23(2): 96-105)
کلیدواژه‌های انگلیسی مقاله ACS,CAD,Urban Population,Young,Age-related differences
نویسندگان مقاله Kamran Ahmed Khan |
National Institute of Cardiovascular Diseases (NICVD), Karachi, Pakistan.

Rajesh Kumar |
National Institute of Cardiovascular Diseases (NICVD), Karachi, Pakistan.

Jehangir Ali Shah |
National Institute of Cardiovascular Diseases (NICVD), Karachi, Pakistan.

Muhammad Naeem Mengal |
National Institute of Cardiovascular Diseases (NICVD), Karachi, Pakistan.

Fawad Farooq |
National Institute of Cardiovascular Diseases (NICVD), Karachi, Pakistan.

Rizwan Khan |
National Institute of Cardiovascular Diseases (NICVD), Sehwan, Pakistan.

Ashok Kumar |
National Institute of Cardiovascular Diseases (NICVD), Hyderabad, Pakistan.

Jawaid Akbar Sial |
National Institute of Cardiovascular Diseases (NICVD), Karachi, Pakistan.

Tahir Saghir |
National Institute of Cardiovascular Diseases (NICVD), Karachi, Pakistan.

Abdul Samad Achakzai |
National Institute of Cardiovascular Diseases (NICVD), Karachi, Pakistan.

Musa Karim |
National Institute of Cardiovascular Diseases (NICVD), Karachi, Pakistan.

نشانی اینترنتی http://journal.iha.org.ir/article_147078_b311ca85ca8c9a87b6cb53cbe7e59176.pdf
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