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Iranian Heart Journal، جلد ۹، شماره ۲، صفحات ۳۷-۴۲
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عنوان انگلیسی Risk Factors for Silent Myocardial Ischemia in Type II Diabetic Patients
چکیده انگلیسی مقاله Background- Silent myocardial ischemia is more common in diabetic patients than others. Early
detection plays an important role in the prevention of acute myocardial infarction and sudden
cardiac death. Routine screening of all diabetics is costly. The aim of this study was to
estimate the prevalence of silent myocardial ischemia in type 2 diabetes and define these highrisk
patients by routine screening tests.
Methods- Between May 2004 and May 2006, this cross-sectional study was performed on 500 type
2 diabetic patients referred to Kerman internal medicine and cardiovascular clinics. Inclusion
criteria were age between 35 and 70 years, absence of symptoms and resting
electrocardiographic signs of ischemia, evidence of retinopathy or peripheral vascular disease,
or at least one major atherogenic risk factor (except diabetes). All the patients underwent
treadmill exercise test or thallium scintigraphy with exercise or dipyridamole injection. Data
were analyzed with chi-square, t-test, and Mann-Whitney U tests.
Results- Five hundred patients, comprised of 232 men and 268 women, were evaluated. Screening
tests were positive in 86 (17.2%) patients. There was a significant statistical relation between
the duration of diabetes, low density lipoprotein cholesterol, family history of coronary artery
disease (CAD), retinopathy, and peripheral vascular disease with silent myocardial ischemia
(P<0.05). The prevalence of silent ischemia was not significantly different between the males
and females (P>0.05). Among the patients with silent ischemia, body mass index was higher
in the females and cigarette smoking was more common in the males (P<0.05).
Conclusion- With regard to the high frequency of silent myocardial ischemia in type 2 diabetes
mellitus, routine silent ischemia screening by exercise stress test should be recommended in
type 2 diabetes if any of these conditions are present: duration of diabetes more than ten years,
family history of CAD, LDL cholesterol higher than 160 mg/dL, retinopathy, or peripheral
vascular disease (Iranian Heart Journal 2008; 9 (2):37-42).
کلیدواژه‌های انگلیسی مقاله type 2 diabetes ■ silent myocardial ischemia ■ coronary artery di
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نشانی اینترنتی http://journal.iha.org.ir/article_183378_e9030479f35ac08d0f0325e629ee175d.pdf
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