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Tanaffos، جلد ۲۰، شماره ۲، صفحات ۱۵۰-۱۵۵
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عنوان انگلیسی Determination of a Cut-off Point for Exhaled Nitric Oxide in the Diagnosis of Asthma in an Iranian Population
چکیده انگلیسی مقاله Background: Asthma is a major source of global social and economic burden; thus, its early detection is important. Measurement of fractional exhaled nitric oxide (FENO) has been used recently considered a good indicator of asthma and also a sensitive and non-invasive method for monitoring airway inflammation. This study was conducted to determine the cut-off point of FENO for the diagnosis of asthma in the studied population. Materials and Methods: The subjects of this cross-sectional diagnostic study were assessed by the FENO test, spirometry, and methacholine challenge test. The best cut-off point of the FENO for the diagnosis of asthma was determined. The data were analyzed by SPSS 20 using student t-test, and Chi-square test and the ROC curves were also drawn. Results: The mean FENO in asthmatic and non-asthmatic subjects was 43.5±33.41 and 17.5±21.48 ppb, respectively (P <0.001). The best cut-off point of the FENO based on the overall sensitivity and specificity was 39.5 ppb. Conclusion: According to the results of this study, symptomatic patients with FENO higher than 39.5 ppb could be considered as asthmatic.
کلیدواژه‌های انگلیسی مقاله Cut-off Point,Exhaled Nitric Oxide,Asthma
نویسندگان مقاله Mohammad Borhani Fard |
Department of Occupational Medicine, Shahid Sadoughi University of Medical Sciences, Yazd, Iran

Mohammad Samet |
Shahid Sadoughi University of Medical Sciences, Yazd, Iran

Mojahede Salmani Nodoushan |
Occupational Medicine Research Center, Iran University of Medical sciences, Tehran, Iran

Amir Houshang Mehrparvar |
Department of Occupational Medicine, Shahid Sadoughi University of Medical Sciences, Yazd, Iran

Amir Bahrami-Ahmadi |
Occupational Medicine Research Center, Iran University of Medical sciences, Tehran, Iran

نشانی اینترنتی https://www.tanaffosjournal.ir/article_248075_a61cc36ec9095a6255634cdcfba2dc10.pdf
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