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Tanaffos، جلد ۱۹، شماره ۲، صفحات ۱۰۸-۱۱۱
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عنوان انگلیسی A Novel Coronavirus Disease (COVID-19): a Review of Host Cell Signaling Pathways
چکیده انگلیسی مقاله Coronaviruses (CoVs) are the largest group of positive-sense RNA viruses. By increasing our understanding of the interactions between CoVs and the host innate immune system, we can evaluate the development and persistence of inflammation in the lungs and reduce the risk of CoV-induced lung inflammation with a new group of genetic variants. Here, we aim to discuss some recent changes in host cell factors that may be used by CoV to promote the proliferation cycle. We also discuss different host cell signaling pathways that can be considered in the host-pathogen interactions at the molecular level. The pandemic of coronavirus disease 2019 (COVID-19), caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has created new challenges for the cultural, economic, and health infrastructures. Therefore, it is important that healthcare systems and physicians recognize a global integrated framework for monitoring the progression of COVID-19 to develop targeted therapies that can potentially save human lives.
کلیدواژه‌های انگلیسی مقاله Coronavirus,Host-pathogen interactions,Signaling pathways
نویسندگان مقاله Hadiseh Mohammadpour |
Dental Research Center, Dentistry Research Institute, Tehran University of Medical Sciences, Tehran, Iran,

Ali Ziai |
Department of Pharmacology, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran,

Makan Sadr |
Virology Research Center, National Research Institutes of Tuberculosis and Lung Diseases (NRITLD), Shahid Beheshti University of Medical Sciences, Tehran, Iran,

Mitra Rezaei |
Virology Research Center, National Research Institutes of Tuberculosis and Lung Diseases (NRITLD), Shahid Beheshti University of Medical Sciences, Tehran, Iran,

Majid Marjani |
Clinical Tuberculosis and Epidemiology Research Center, NRITLD, Shahid Beheshti University of Medical Sciences, Tehran, Iran

Payam Tabarsi |
Clinical Tuberculosis and Epidemiology Research Center, NRITLD, Shahid Beheshti University of Medical Sciences, Tehran, Iran

نشانی اینترنتی https://www.tanaffosjournal.ir/article_239654_b32e8a8a057beef0999b0009450de9bf.pdf
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