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Tanaffos، جلد ۱۷، شماره ۴، صفحات ۲۱۱-۲۲۲
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عنوان انگلیسی Protective Effects of Thymoquinon on Pulmonary Disorders in Experimental Studies
چکیده انگلیسی مقاله Lung as vital organ is exposed to many injurious agents that can cause inflammation and oxidative stress, which are potential causes in the pathogenesis of lung diseases. Nigella sativa, usually introduced as black seed, has been considered for treatment of various diseases and is one the most widely investigated herbs. Thymoquinone (TQ) is the major component of the volatile oil of black seed (54%) which has been indicated to anti-oxidant, antiinflammatory and anti-neoplastic properties. There is interesting to study on TQ effect as a therapeutic agent for various diseases in both in vivo and in vitro conditions. In this comprehensive review, we summarized the recent studies related to the effectiveness of TQ on lung disorders such as inflammatory lung diseases, lung fibrosis, asthma and lung cancer. It is concluded that TQ with anti-inflammatory, anti- oxidant, anti-asthmatic and anti- tumor activity can provide therapeutic effects against lung disorders. However, more investigation is needed to produce TQ as a pharmaceutical preparation for human studies.
کلیدواژه‌های انگلیسی مقاله Thymoquinone,Lung inflammation,Asthma,Lung fibrosis,Lung cancer
نویسندگان مقاله Mohammad-Foad Noorbakhsh |
Division of Pharmacology and Toxicology, Department of Basic Sciences, School of Veterinary Medicine, Shiraz University, Shiraz, Iran

Hanieh Shaterzadeh- Yazdi |
Research Center of Pardis Hospital, Mashhad, Iran.

Farzad Hayati |
Research Center of Pardis Hospital, Mashhad, Iran.

Saeed Samarghandian |
Noncommunicable Disease Research Center, Neyshabur University of Medical Sciences, Neyshabur, Iran

Tahereh Farkhondeh |
Cardiovascular Diseases Research Center, Birjand University of Medical Sciences, Birjand, Iran.

نشانی اینترنتی https://www.tanaffosjournal.ir/article_240026_ed6ca71f38ce537f19fda26ce3d36c58.pdf
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