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Tanaffos، جلد ۱۴، شماره ۳، صفحات ۱۷۲-۱۷۶
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عنوان انگلیسی High Seroprevalence of Bordetella pertussis in Patients with Chronic Obstructive Pulmonary Disease: A Case-Control Study
چکیده انگلیسی مقاله Background: Bordetella pertussis has been suggested to take part in the acute exacerbation of chronic obstructive pulmonary disease (COPD). The aim of this study was to investigate the association between B. pertussis and COPD. Materials and Methods: In this case-control study, 90 patients with COPD and 90 age- and sex- matched control subjects were included. Serum samples were tested for anti-B. pertussis IgG and IgA by ELISA. A physician completed a questionnaire including demographic characteristics, habitual history and spirometric findings for each patient. Results: Of 90 patients with chronic obstructive pulmonary disease, 66 (51%) had mild, 31 (34.4%) had moderate, and 13 (14.4%) had severe disease. There was no significant association between B. pertussis IgA seropositivity and COPD. Serum levels of anti- B. pertussis IgG were significantly higher in patients with COPD than in the control subjects (P < 0.001). No association was observed between B. pertussis infection and severity of COPD. Conclusion: The results suggest that there is an association between B. pertussis infection and COPD. Further studies should be planned to investigate the potential pathogenic mechanisms underlying these associations.
کلیدواژه‌های انگلیسی مقاله Bordetella pertussis,Chronic Obstructive Pulmonary Disease,Whooping Cough
نویسندگان مقاله Seyyed Hamid Hashemi |
Brucellosis Research Center, Hamedan University of Medical Sciences, Hamedan, Iran,

Ebrahim Nadi |
Department of Internal Medicine, Division of Pulmonary Diseases, Hamedan University of Medical Sciences, Hamedan, Iran,

Mehrdad Hajilooi |
Department of Immunology, Hamedan University of Medical Sciences, Hamedan, Iran

Mohammad-Ali SeifRabiei |
Brucellosis Research Center, Hamedan University of Medical Sciences, Hamedan, Iran,

Atefeh Samaei |
Brucellosis Research Center, Hamedan University of Medical Sciences, Hamedan, Iran,

نشانی اینترنتی https://www.tanaffosjournal.ir/article_240832_5111ee77ea7d4cd9745a8694ca926b03.pdf
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