این سایت در حال حاضر پشتیبانی نمی شود و امکان دارد داده های نشریات بروز نباشند
Tanaffos، جلد ۹، شماره ۱(winter)، صفحات ۲۸-۳۳
عنوان فارسی
چکیده فارسی مقاله
کلیدواژه‌های فارسی مقاله
عنوان انگلیسی Correlation of CRP and Serum Fibrinogen Levels with Disease Severity, Clinical Factors and Pulmonary Function Tests in COPD Patients
چکیده انگلیسی مقاله Background: Chronic obstructive pulmonary disease (COPD) is a progressive chronic disease and C-reactive protein (CRP) and fibrinogen are considered as main systemic inflammatory biomarkers. This study aimed to evaluate the alterations of CRP and serum fibrinogen levels in COPD patients and their correlation with the severity of disease, arterial O2 saturation and opium or cigarette consumption. Materials and Methods: This was a descriptive case-control study conducted on 31 COPD patients and 29 healthy controls selected by using easy sampling method in Afzalipour Hospital. Serum levels of CRP and fibrinogen were measured by ELISA method and analyzed using SPSS software version 15. Results: The mean serum level of CRP in the understudy patients (13.15±13.72 mg/L) was significantly higher than that of the controls (3.53±1.12 mg/L)(P=0.000). However, no significant difference was found in the mean serum level of fibrinogen between cases (3.81±0.93 mg/dl) and controls (3.72±0.9 mg/dl)(p=0.82). Also, no significant correlation was detected between the serum level of CRP or fibrinogen and severity of the disease (P=0.92 and P=0.58, respectively). A statistically significant relationship was found between the serum levels of CRP and fibrinogen and arterial O2 saturation (P=0.02). There was no significant difference in the serum levels of CRP and fibrinogen between the opium users (p=0.19) and other patients (p=0.15). Conclusion: According to our study results, COPD, per se, can increase the inflammatory biomarkers including CRP. Raised serum level of CRP is indicative of systemic inflammation which results in extra-pulmonary manifestations like cardiovascular diseases, cerebrovascular accidents, osteoporosis, and cachexia. Therefore, with routine measurement of this marker, we can evaluate the severity of systemic inflammation in these patients and choose the best treatment accordingly. (Tanaffos 2010; 9(1): 28-33)
کلیدواژه‌های انگلیسی مقاله Fibrinogen,Chronic Obstructive Pulmonary Disease,C-reactive protein,Pulmonary function test
نویسندگان مقاله Mitra Samareh-Fekri |
Department of Pulmonary Medicine,

Syed Abdol-Rahim Khorasani |
Department of Pulmonary Medicine,

Maliheh Shadkam-Farokhi |
Physiology Research Center, Kerman University of Medical Sciences, KERMAN-IRAN.

نشانی اینترنتی https://www.tanaffosjournal.ir/article_241189_a8d8581b6ed2f9dc6c45531a60825513.pdf
فایل مقاله فایلی برای مقاله ذخیره نشده است
کد مقاله (doi)
زبان مقاله منتشر شده en
موضوعات مقاله منتشر شده
نوع مقاله منتشر شده
برگشت به: صفحه اول پایگاه   |   نسخه مرتبط   |   نشریه مرتبط   |   فهرست نشریات