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Iranian Journal of Pathology، جلد ۱۸، شماره ۱، صفحات ۹۶-۱۰۳
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عنوان انگلیسی Frequency of HER2 Expression, MMR Deficiency, and PI3KCA Mutation in Pretreated Surgical Specimens of Patients with Esophageal Squamous Cell Carcinoma in Iran Cancer Institute
چکیده انگلیسی مقاله Background & Objective: Iran is located in the esophageal cancer geographical belt. As multiple genetic alterations are responsible for the molecular pathogenesis of esophageal squamous cell cancer (ESCC), the role and frequency of HER2 expression, MMR deficiency, and PI3KCA mutation are not well defined.
Methods: We carried out HER2/neu expression, dMMR/MSI high, and PI3KCA mutation analysis in specimens of patients with ESCC. We accessed archival tissue blocks related to specimens of 68 ESCC cases at the time of surgery following neoadjuvant chemoradiation. These patients underwent surgery during 2013-2018 at the Cancer Institute of Iran affiliated with the Tehran University of Medical Sciences in Tehran.
Results: None of the patients showed HER2 expression, dMMR/MSI high, or PI3K mutations.
Conclusion: dMMR/MSI-H and PI3KCA mutation and HER2 expression may not be reliable andfrequent targets for systemic therapy in patients with esophageal SCC.
کلیدواژه‌های انگلیسی مقاله DNA Mismatch Repair,Esophageal Neoplasms,HER Family Receptor,Kinase,Squamous cell carcinoma
نویسندگان مقاله Samaneh Salarvand |
Department of Clinical and Anatomical Pathology, Cancer Institute, Tehran University of Medical Sciences, Tehran, Iran

Farzaneh Bagheri |
Department of Radiation Oncology, Cancer Institute, Tehran University of Medical Sciences, Tehran, Iran

Mahsa Gholizadeh |
Radiation Oncology Research Center, Cancer Research Institute, Tehran University of Medical Sciences, Tehran, Iran

Sima Sharifi |
Department of Clinical and Anatomical Pathology, Cancer Institute, Tehran University of Medical Sciences, Tehran, Iran

Pooneh Panahi |
Department of Clinical and Anatomical Pathology, Cancer Institute, Tehran University of Medical Sciences, Tehran, Iran

Ebrahim Esmati |
Department of Radiation Oncology, Cancer Institute, Tehran University of Medical Sciences, Tehran, Iran

Marzieh Lashkari |
Department of Radiation Oncology, Cancer Institute, Tehran University of Medical Sciences, Tehran, Iran

Amirmohsen Jalaeefar |
Department of Oncosurgery, Cancer Institute, Tehran University of Medical Sciences, Tehran, Iran

Mohammad Shirkhoda |
Department of Oncosurgery, Cancer Institute, Tehran University of Medical Sciences, Tehran, Iran

Reza Shahsiah |
Department of Clinical and Anatomical Pathology, Cancer Institute, Tehran University of Medical Sciences, Tehran, Iran

Reza Ghalehtaki |
Department of Radiation Oncology, Cancer Institute, Tehran University of Medical Sciences, Tehran, Iran

نشانی اینترنتی https://ijp.iranpath.org/article_703821_04fdebc58ed545f8f73d67fe107dcfc1.pdf
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