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Iranian Journal of Pathology، جلد ۱۷، شماره ۴، صفحات ۴۹۶-۴۹۹
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عنوان انگلیسی Crescentic Glomerulonephritis, A Rare Presentation of Alport Syndrome
چکیده انگلیسی مقاله Crescentic glomerulonephritis (GN) is a feature of severe glomerular injury. Anti-GBM disease, immune-complex mediated glomerulonephritis, and ANCA-associated vasculitis are the main causes of crescentic GN. Alport syndrome is a progressive form of hereditary nephritis presenting with hematuria and progression to proteinuria and renal failure. Herein we present a 16-year-old male with rapidly progressive glomerulonephritis syndrome, sensory-neural hearing loss, and a family history of hematuria and proteinuria in his mother and aunt. Light microscopic examination shows cellular crescent in glomeruli. In an electron microscopy study, GBM changes compatible with Alport syndrome were identified. Alport syndrome rarely can be presented as crescentic GN. Electron microscopy is necessary for the diagnosis of this type of pauci-immune crescentic glomerulonephritis.
کلیدواژه‌های انگلیسی مقاله Alport,Crescentic glomerulonephritis,Hereditary nephritis
نویسندگان مقاله Tahereh Malakoutian |
Department of Nephrology, Shahid Hasheminejad Kidney Center, Iran University of Medical Sciences, Tehran, Iran

Fatemeh Nili |
Department of Pathology, Imam Khomeini Hospital Complex, Tehran University of Medical Sciences, Tehran, Iran

Sholeh Ghasemi Darbrood |
Department of Nephrology, Shahid Hasheminejad Kidney Center, Iran University of Medical Sciences, Tehran, Iran

Samaneh Salarvand |
Department of Pathology, Imam Khomeini Hospital Complex, Tehran University of Medical Sciences, Tehran, Iran

Mitra Mehrazma |
Department of Pathology, Shahid Hasheminejad Kidney Center, Iran University of Medical Sciences, Tehran, Iran

نشانی اینترنتی https://ijp.iranpath.org/article_254728_7a41bf41d127120cb2ba84e76bf58517.pdf
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