این سایت در حال حاضر پشتیبانی نمی شود و امکان دارد داده های نشریات بروز نباشند
Iranian Journal of Pathology، جلد ۱۷، شماره ۳، صفحات ۲۶۸-۲۷۴
عنوان فارسی
چکیده فارسی مقاله
کلیدواژه‌های فارسی مقاله
عنوان انگلیسی Revisiting Metaplastic Carcinoma of Breast: An Emphasis on the Clinico-pathological and Immunohistochemical Variables Analyzed at a Tertiary Cancer Centre in South India
چکیده انگلیسی مقاله Background & Objective: Metaplastic carcinoma is a diverse variant of invasive breast carcinomas (IBC) characterized by dedifferentiation of malignant cells towards squamous and/or mesenchymal elements. It accounts for 0.3-1.2% of all IBC. These tumors are typically triple-negative by hormonal profiling with a high proliferation index and a dismal prognosis. Lymph node metastasis is an unusual feature in metaplastic carcinoma.
Methods: The present study analyses 30 cases (26 cases of modified radical mastectomy and 4 cases of lumpectomy) of metaplastic carcinoma over 2018-2020 (3 years). Four oncopathologists reviewed routine histopathologic and immunohistochemical-stained slides. The clinical details were collected from the Medical Records Department of the Cancer Institute.
Results: A total of 20 (66.67%) cases were patients >50 years of age, 21(70%) out of which were diagnosed as invasive carcinoma, grade 3 according to the Nottingham histological score. Five (16.7%) cases presented with lymph node metastasis. While immunohistochemically 28 (93.3%) cases were triple-negativeCK5/6, P63, EGFR, and Ki-67 (more than 40%) positivity was noted in 25 (83.3%) , 26 (86,7%) , 20 (66.7%), and 25 (83.3%) cases, respectively.
Conclusion: Metaplastic carcinoma is characteristically triple-negative breast malignancies (TNBC) exhibiting a high Ki-67 index and a lower rate of lymph node metastasis. CK5/6, p63, and EGFR are pertinent immunohistochemical markers that may aid in diagnosis. However, those markers are non-specific for the disease and morphologic features are always the key to the diagnosis of the process.
کلیدواژه‌های انگلیسی مقاله CK cytokeratin,EGFR epidermal growth factor receptor,IBC Invasive breast carcinoma,IHC immunohistochemistry,NST No special type,MC Metaplastic carcinoma
نویسندگان مقاله Geetha V Patil Okaly1 |
Department of Pathology, Kidwai Memorial Institute of Oncology, Bangalore, India

Akshatha C |
Department of Pathology, Kidwai Memorial Institute of Oncology, Bangalore, India

Sandhya N |
Department of Pathology, Kidwai Memorial Institute of Oncology, Bangalore, India

Akina Prakash |
Department of Pathology, Kidwai Memorial Institute of Oncology, Bangalore, India

M N Suma |
Department of Pathology, Kidwai Memorial Institute of Oncology, Bangalore, India

Ashwini Nargund |
Department of Pathology, Kidwai Memorial Institute of Oncology, Bangalore, India

Shankar Anand |
Department of Pathology, Kidwai Memorial Institute of Oncology, Bangalore, India

C Ramachandra |
Department of Surgical Oncology, Kidwai Memorial Institute of Oncology, Bangalore, India

Libin Babu Cherian |
Department of Pathology, Kidwai Memorial Institute of Oncology, Bangalore, India

نشانی اینترنتی https://ijp.iranpath.org/article_254061_7274cd5f8df15234dab1b0e6d700d759.pdf
فایل مقاله فایلی برای مقاله ذخیره نشده است
کد مقاله (doi)
زبان مقاله منتشر شده en
موضوعات مقاله منتشر شده
نوع مقاله منتشر شده
برگشت به: صفحه اول پایگاه   |   نسخه مرتبط   |   نشریه مرتبط   |   فهرست نشریات