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Iranian Journal of Pathology، جلد ۱۷، شماره ۲، صفحات ۱۵۰-۱۵۸
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عنوان انگلیسی Clinicopathological Significance of PTEN Expression and Its Prognostic Effect in Colorectal Adenocarcinoma Patients
چکیده انگلیسی مقاله Background & Objective: Phosphatase and tensin homolog (PTEN) is a tumor suppressor gene located at chromosome 10. PTEN is a regulator of the PI3K/AKT signaling pathway that inhibits cell proliferation and promotes apoptosis. PTEN loss of function occurs in a spectrum  of cancers, including colorectal adenocarcinoma. This study aimed to investigate the probable correlation of negative PTEN expression with clinicopathological features and colorectal adenocarcinoma (CRC) patients'''' survival.
Methods: In this cross-sectional study using Immunohistochemistry stainingPTEN expression status on 151 CRC tissues was evaluated. Then the results of IHC staining was compared to those of clinicopathological features. The relationship between PTEN and KRAS mutation status was also investigated.
Results: Of 151 CRC samples, 89 (58.9%) were negative for PTEN expression. Loss of PTEN expression was associated with KRAS mutation (P
کلیدواژه‌های انگلیسی مقاله Adenocarcinoma,Clinicopathology,Colorectal cancer,PTEN,Prognostic Factors
نویسندگان مقاله Zohreh Mirzapour Abbas Abadi |
Department of Molecular Medicine, Faculty of Medical Sciences, Qazvin University of Medical Sciences, Qazvin, Iran

Fatemeh Samiee Rad |
Department of Pathology, Faculty of Medical School, Qazvin University of Medical Sciences, Qazvin, Iran

Dariush Hamedi Asl |
Department of Pathology and Molecular Medicine, Mehr Laboratory, Hashtgerd, Iran

Babak Rahmani |
Department of Molecular Medicine, Faculty of Medical Sciences, Qazvin University of Medical Sciences, Qazvin, Iran

Mahmood Soleimani Dodaran |
Qazvin University of Medical Sciences

Amir Peimani |
Medical Microbiology Research Center, Qazvin University of Medical Sciences, Qazvin, Iran

نشانی اینترنتی https://ijp.iranpath.org/article_251010_4585a0dc5fedb827cd99b4a71947a7c0.pdf
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