این سایت در حال حاضر پشتیبانی نمی شود و امکان دارد داده های نشریات بروز نباشند
Iranian Journal of Pathology، جلد ۱۷، شماره ۲، صفحات ۲۱۷-۲۲۴
عنوان فارسی
چکیده فارسی مقاله
کلیدواژه‌های فارسی مقاله
عنوان انگلیسی A Novel Subset of Triple-Negative Breast Cancers with Unique Histology and Immunohistochemical Expression
چکیده انگلیسی مقاله Background & Objective: Triple-Negative Breast Carcinoma (TNBC) is characterized by an absence of estrogen receptor, progesterone receptor and HER2 neu expression, with distinct molecular, histological and clinical features, aggressive clinical course and a poor prognosis. The objective was to evaluate the expression of Cytokeratin5/6 (CK 5/6), Epidermal Growth Factor Receptor 1 (EGFR 1), E-cadherin and Androgen receptor in tissue sections of TNBC.
Methods: All modified radical mastectomy samples received negative for the three markers were subjected to further studies with CK5/6, EGFR 1, E- cadherin and Androgen receptor staining. The clinical and pathological data were tabulated and statistically analysed using the Chi-square test, and cross-tabulation was done to assess the correlation between these markers.
Results: Of 94 samples classified as TNBC, 31 (33%) were positive for CK 5/6, 47 (50%) for EGFR, 32 (34%) for E Cadherin and Androgen receptor, respectively. We had one positive patient for all four markers, 13 patients were negative for all four. Thirty-five cases were positive for only one marker, 32 were positive for two markers, and 13 were positive for three markers. Analysis revealed certain interesting patterns, namely - E cadherin was the most common isolated marker expressed in our cohort of TNBC with 15 of 35 positives.
Conclusion: This study highlights the presence of a unique subtype of TNBC, which are negative for all the four markers studied here, with unique histomorphology of absent tumour necrosis and stromal lymphocytic infiltration being unique.
کلیدواژه‌های انگلیسی مقاله Androgen receptor,Breast cancer,CK 5/6,EGFR,E- cadherin,Triple-negative
نویسندگان مقاله Swaminathan Kalyanasundaram |
Tirunelveli Medical College, Tamilnadu, India

Shantaraman Kalyanaraman |
Tirunelveli Medical College, Tamilnadu, India

Hidhaya Kaleelullah Fathima |
Tirunelveli Medical College, Tamilnadu, India

Vidhya Mohan |
Tirunelveli Medical College, Tamilnadu, India

Kavitha Selvaraj |
Tirunelveli Medical College, Tamilnadu, India

نشانی اینترنتی https://ijp.iranpath.org/article_250922_68ff5443c55505e7d8968cf414d83de0.pdf
فایل مقاله فایلی برای مقاله ذخیره نشده است
کد مقاله (doi)
زبان مقاله منتشر شده en
موضوعات مقاله منتشر شده
نوع مقاله منتشر شده
برگشت به: صفحه اول پایگاه   |   نسخه مرتبط   |   نشریه مرتبط   |   فهرست نشریات