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Iranian Journal of Pathology، جلد ۱۷، شماره ۱، صفحات ۲۳-۲۸
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عنوان انگلیسی Kindlin1 As a Sex and Location Specific Diagnostic Marker in Gastric Cancer Patients
چکیده انگلیسی مقاله Background & Objective: Gastric cancer (GC) is considered one of the main reasons for cancer-related mortalities among Iranians. Kindlin-1 is an adhesion protein member of integrin-interacting proteins, regulating integrin activation through direct interaction with β-integrin. Therefore, kindlin-1 can be involved in the regulation of cell proliferation and adhesion. In the present study, we assessed the possible role of kindlin-1 in GC progression and metastasis.
Methods:  KINDLIN1 messenger RNA (mRNA) expression was assessed in tumor tissues from 80 GC patients in comparison with normal tissues using real-time polymerase chain reaction (PCR).
Results: The levels of KINDLIN1 expressions were significantly correlated with sex (P=0.05) and tumor location (P=0.002). KINDLIN1 expression was also significantly associated with lymph node metastasis among the helicobacter pylori (HP)-negative cases (P=0.001). Moreover, a significant association between age and KINDLIN1 expression was observed among the HP-positive cases (P=0.039).
Conclusion: In the present study, we introduced KINDLIN1 as a location-specific marker for cardia gastric carcinoma. Moreover, it was observed that KINDLIN1 could be used as a sex-dependent diagnostic marker of GC patients.
کلیدواژه‌های انگلیسی مقاله Gastric Cancer,Cell adhesion,Integrin,Helicobacter pylori,Extra Cellular Matrix
نویسندگان مقاله Mohammad Reza Abbaszadegan |
Medical Genetics Research Center, Mashhad University of Medical Sciences, Mashhad, Iran

Negin Taghehchian |
Department of Chemistry, Faculty of Science, Ferdowsi University of Mashhad, Mashhad, Iran

Azadeh Aarabi |
Immunology Research Center, Mashhad University of Medical Sciences, Mashhad, Iran

Sohrab Nozari |
Student Research Committee, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran

Ehsan Saburi |
Department of Medical Genetics and Molecular Medicine, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran

Meysam Moghbeli |
Department of Medical Genetics and Molecular Medicine, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran

نشانی اینترنتی https://ijp.iranpath.org/article_247995_13dc71a85e4240fe3ff5585e32c05565.pdf
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