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Iranian Journal of Pathology، جلد ۱۷، شماره ۱، صفحات ۳۷-۴۷
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عنوان انگلیسی Changes of Routine Hematological Parameters in COVID-19 Patients: Correlation with Imaging Findings, RT-PCR and Outcome
چکیده انگلیسی مقاله Background & Objective: Coronavirus disease 2019 (COVID-19) is progressively spreading, and many researchers have focused on the prognostic value of laboratory analyses. This study reviewed routine blood parameters, upper respiratory viral load, and chest imaging in recovered and expired COVID-19 patients and evaluated possible correlations.
Methods: In this retrograde study, 138 COVID-19 cases were enrolled. Chest tomography scores of patients, routine hematologic and  biochemical parameters, and respiratory viral loads were measured. Furthermore, their correlation with severity of disease  and the outcome was investigated during a week of admission.
Results: The mean age of participants was 58.6±16;  36.2% of whom were diagnosed as critical, 8.7% expired, and 46% showed less than 50% lung opacity. The expiring rate was only correlated to the severity of illness and viral load. During admission, hemoglobin concentration was decreased in critical patients (from 11.49±0.27 to 10.59±0.36, P=0.042) and also among CT-scan scoring groups (P=0.000), while neutrophils (P=0.04), WBC (P=0.03), and platelets (P=0.000) count were increased. In patients with more than 50% lung opacity, leukocyte counts were decreased, but neutrophil and platelets counts showed raise (all P<0.05), while other hematologic parameters did not change. CRP and LDH demonstrated no  increase based on the severity of the illness, RT-PCR viral loads and/or outcome. However, both CRP and LDH were increased in patients with more than 50% lobal opacity (CRP: 69.3±9.9 to 1021.1±7.5 and LDH:589.5±93.2 to 1128.6±15.81, P<0.05).
Conclusion: We found that hemoglobin, white blood cells, neutrophil, lymphocytes, and platelets count together with chest tomography score might be beneficial for expedition the  diagnosis, assessmen the severity of the disease, and outcome in the hospitalized cases, while CRP and LDH might be considered as the consequence of lung involvement.
کلیدواژه‌های انگلیسی مقاله COVID-19,Hematology,Tomography scanners,Viral load
نویسندگان مقاله Abdolreza Javadi |
Department of Pathology and Laboratory Medicine, Imam Hossein Hospital, Shahid Beheshti University of Medical Sciences, Tehran, Iran

Shahriar Dabiri |
Department of Pathology, Afzalipour Medical School, Kerman, Iran

Manzumeh Shamsi Meymandi |
Pathology and Stem Cells Research Center, Kerman Medical School, Kerman University of Medical Sciences, Kerman, Iran

Mohammad Hashemi-Bahremani |
Department of Pathology and laboratory medicine, Imam Hossein Hospital, Shahid Beheshti University of Medical Sciences, Tehran, Iran

Hussein Soleimantabar |
Department of Radiology, Imam Hossein Hospital, Shahid Beheshti University of Medical Sciences, Tehran, Iran

Bahram Dabiri |
Department of Pathology, Resident NYU Langone Health, Mineloa, NY, USA

Houman Vosough |
Imam Hossein Central Medical Laboratory, Shahid Beheshti University of Medical Sciences, Tehran, Iran

Maryam Gheidi Sharan |
Imam Hossein Central Medical Laboratory, Shahid Beheshti University of Medical Sciences, Tehran, Iran

Farnoosh Sedaghati |
Imam Hossein Central Medical Laboratory, Shahid Beheshti University of Medical Sciences, Tehran, Iran

نشانی اینترنتی https://ijp.iranpath.org/article_248592_62c30ecc501e40442e070a9ab5c6da4e.pdf
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