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Iranian Journal of Pathology، جلد ۱۶، شماره ۲، صفحات ۲۱۵-۲۲۱
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عنوان انگلیسی Polyomavirus Associated Nephropathy: Frequency and Graft Survival Analysis in Northeast of Iran
چکیده انگلیسی مقاله Background & Objectives: Polyomavirus-associated nephropathy (PVAN), mainly caused by the BK virus, is one of the most important infectious complications of kidney transplantation. The leading histopathologic characteristics of PVAN is viral cytopathic effects, such as nucleomegaly with smudged or clumped chromatin and intranuclear ground-glass inclusion, mostly in tubular epithelial cells. Moreover, tubular necrosis, tubulitis, interstitial inflammation, atrophy, and fibrosis have been noted. Positive immunohistochemistry (IHC) staining for SV-40 highlights the infected epithelial cells of renal tubules.
Methods: A total of 85 core needle biopsies of transplanted kidneys were evaluated histologically and were stained for SV-40 using the IHC method. In addition, a follow-up of graft failure was performed.
Results: Our findings revealed that the frequency of polyomavirus infection in kidney transplant patients in the Northeast of Iran is 4.7%. There was no significant correlation between PVAN and graft rejection. Although a higher rate of graft loss was observed in PVAN patients, in comparison with non-PVAN patients (25% vs. 14.8%), the difference was not statistically significant. Moreover, patients with immunohistochemically confirmed PVAN and those with histopathologic features of viral-like cytopathic effects had significantly lower graft survival in the follow-up period (42.5 vs. 196.8 months and 109.4 vs. 205.7 months, respectively).
Conclusion: The frequency of polyomavirus infection in kidney transplant patients in the Northeast of Iran is 4.7%. There was no significant correlation between PVAN and graft rejection. Furthermore, we observed that polyomavirus infection accelerates the course of graft loss.
کلیدواژه‌های انگلیسی مقاله Frequency,Graft survival analysis,Polyomavirus-associated nephropathy
نویسندگان مقاله Shirin Taraz Jamshidi |
Kidney Transplantation Complications Research Center, Mashhad University of Medical Sciences, Mashhad. Iran

Khadijeh Sajjadian |
Student Research Committee, Mashhad University of Medical Sciences, Mashhad, Iran

Maryam Emadzadeh |
Clinical Research Unit, Mashhad University of Medical Sciences, Mashhad, Iran

Malihe Saber Afsharian |
Department of Pathology, Faculty of medicine, Mashhad Azad university, Mashhad, Iran.

Mahmoud Reza Kalantari |
Department of Pathology, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran

Anita Alenabi |
Cancer Molecular Pathology Research Center, Mashhad University of Medical Sciences, Mashhad, Iran

Abbas Ali Zeraati |
Kidney Transplantation Complications Research Center, Mashhad University of Medical Sciences, Mashhad. Iran

Ali Emadzadeh |
Kidney Transplantation Complications Research Center, Mashhad University of Medical Sciences, Mashhad. Iran

نشانی اینترنتی https://ijp.iranpath.org/article_242849_6285859d178ee4ce553a63ca709f96ad.pdf
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